THERE have been reports indicating that the normal phenotypic expression of histocompatibility antigens is altered on tumour cells1, and a disappearance or diminution of H–2 expression on murine tumour cells has been demonstrated2,3. The nature of these changes has so far remained unclear. It has also been shown that H–2D and H–2K antigens are important in T-cell mediated lysis of virus infected or transformed syngeneic cells4,5. One explanation for these phenomena proposes that H–2 antigens are modified by association with additional cell-surface molecules to form a neoantigen or ‘altered self’6. We report here immunochemical evidence for alteration of H–2 antigens on tumour cells by association with additional proteins.
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CALLAHAN, G., ALLISON, J. H–2 Antigens on a murine lymphoma are associated with additional proteins. Nature 271, 165–167 (1978) doi:10.1038/271165a0
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