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Spatial configuration of mRNA 5′-terminus

Abstract

Nuclear magnetic resonance investigation has revealed that the 5′-terminus m7 G5′ ppp5′ Am of mRNA displays a spatial configuration in which the bases form stacked arrays. Details of the conformation as derived from coupling constants, shift trends and ring current considerations are discussed.

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References

  1. Rottman, F., Shatkin, A. J. & Perry, R. P. Cell 3, 197–199 (1974).

    Article  CAS  Google Scholar 

  2. Furuichi, Y. & Miura, K.-I. Nature 253, 374–375 (1975).

    Article  ADS  CAS  Google Scholar 

  3. Furuichi, Y., Morgan, M., Muthukrishnan, S. & Shatkin, A. J. Proc. natn. Acad. Sci. U.S.A. 72, 362–366 (1975).

    Article  ADS  CAS  Google Scholar 

  4. Furuichi, Y., Muthukrishnan, S. & Shatkin, A. J. Proc. natn. Acad. Sci. U.S.A. 72, 742–745 (1975).

    Article  ADS  CAS  Google Scholar 

  5. Urushibara, T., Furuichi, Y., Nishmura, C. & Miura, K.-I. FEBS Lett. 49, 385–389 (1975).

    Article  CAS  Google Scholar 

  6. Wei, C. M. & Moss, B. Proc. natn. Acad. Sci. U.S.A. 72, 318–322 (1975).

    Article  ADS  CAS  Google Scholar 

  7. Abraham, G., Rhodes, D. P. & Banerjee, A. K. Nature 255, 37–40 (1975).

    Article  ADS  CAS  Google Scholar 

  8. Muthukrishnan, S., Both, G. W., Furuichi, Y. & Shatkin, A. J. Nature 255, 33–37 (1975).

    Article  ADS  CAS  Google Scholar 

  9. Furuichi, Y. et al. Proc. natn. Acad. Sci. U.S.A. 72, 1904–1908 (1975).

    Article  ADS  CAS  Google Scholar 

  10. Adams, J. & Cary, S. Nature 255, 28–33 (1975).

    Article  ADS  CAS  Google Scholar 

  11. Furuichi, Y., LaFiandra, A. & Shatkin, A. J. Nature 266, 235–241 (1977).

    Article  ADS  CAS  Google Scholar 

  12. Muthukrishnan, S., Morgan, M., Banerjee, A. K. & Shatkin, A. J. Biochemistry 15, 5761–5768 (1976).

    Article  CAS  Google Scholar 

  13. Shafritz, D. et al. Nature 261, 291–294 (1976).

    Article  ADS  CAS  Google Scholar 

  14. Hickey, E. D., Weber, L. A. & Baglioni, C. Proc. natn. Acad. Sci. U.S.A. 73, 19–23 (1976).

    Article  ADS  CAS  Google Scholar 

  15. Hickey, E. D., Weber, L. A., Baglioni, C., Kim, C. H. & Sarma, R. H. J. molec. Biol. 109, 173–183 (1977).

    Article  CAS  Google Scholar 

  16. Singh, H., Herbut, M. H., Lee, C. H. & Sarma, R. H. Biopolymers 15, 2167–2184 (1976).

    Article  CAS  Google Scholar 

  17. Lee, C. H. & Sarma, R. H. Biochemistry 15, 697–704 (1976).

    Article  CAS  Google Scholar 

  18. Lee, C. H., Ezra, F. S., Kondo, N. S., Sarma, R. H. & Danyluk, S. S. Biochemistry 15, 3627–3639 (1976).

    Article  CAS  Google Scholar 

  19. Lee, C. H. & Sarma, R. H. J. Am. chem. Soc. 98, 3541–3548 (1976).

    Article  CAS  Google Scholar 

  20. Sarma, R. H. & Mynott, R. J. J. Am. chem. Soc. 95, 7470–7480 (1973).

    Article  CAS  Google Scholar 

  21. Sarma, R. H. & Mynott, R. J. Conform. Biol. Molec. Polym., Proc. Jerusalem Chem. Biochem. 5, 591–626 (1973).

    CAS  Google Scholar 

  22. Evans, F. E. & Sarma, R. H. Biopolymers 13, 2117–2132 (1974).

    Article  CAS  Google Scholar 

  23. Giessner-Prettre, C. & Pullman, B. J. theor. Biol. 65, 189–201 (1977).

    Article  CAS  Google Scholar 

  24. Giessner-Prettre, C. & Pullman, B. J. theor. Biol. 65, 171–188 (1977).

    Article  CAS  Google Scholar 

  25. Giessner-Prettre, C., Pullman, B., Borer, P. N., Kan, L.-S. & Ts'o, P. O. P. Biopolymers 15, 2277–2286 (1976).

    Article  CAS  Google Scholar 

  26. Giessner-Prettre, C. & Pullman, B. J. theor. Biol. 27, 87–95 (1970).

    Article  CAS  Google Scholar 

  27. Ts'o, P. O. P., Kondo, N. S., Schweizer, M. P. & Hollis, D. P. Biochemistry 8, 997–1029 (1969).

    Article  CAS  Google Scholar 

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Kim, C., Sarma, R. Spatial configuration of mRNA 5′-terminus. Nature 270, 223–227 (1977). https://doi.org/10.1038/270223a0

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  • DOI: https://doi.org/10.1038/270223a0

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