Abstract
THE tumour-dormant state is one in which tumour cells persist in a clinically normal host for prolonged periods. Tumour dormancy is a potentially unstable state and may culminate in either destruction of all tumour cells or death of the host due to tumour outgrowth. We report here two systems in which tumour-dormant states could be established with transplantable lymphoma cells inoculated into specifically immunised syngeneic murine hosts. A high percentage of mice kept for long-term observation eventually developed tumours and in both systems, tumour cells could be isolated from mice during a prolonged period of clinical normality.
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WEINHOLD, K., GOLDSTEIN, L. & WHEELOCK, E. Tumour-dormant states established with L5178Y lymphoma cells in immunised syngeneic murine hosts. Nature 270, 59–61 (1977). https://doi.org/10.1038/270059a0
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DOI: https://doi.org/10.1038/270059a0
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