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Sister chromatid exchange and chromatid interchange as possible manifestation of different DNA repair processes

Nature volume 269, pages 623–625 (1977)Cite this article

Abstract

SISTER chromatid exchange (SCE) is a symmetrical exchange between a newly duplicated chromatid and its sister1. The demonstration that many agents that damage DNA also increase the frequency of SCE2 suggests that SCE is a reflection of a basic DNA repair process, and perhaps a cytological manifestation of post-replication repair of a recombinational character2–6. The question then arises as to the correlation between SCE and chromatid aberration, particularly chromatid interchange (CI), which also occurs as a consequence of exchange between newly duplicated chromatids7,8. To investigate whether these two types of exchange are due to the same molecular event, I have studied the reaction of SCE and CI to caffeine and cyclo-heximide in endoreduplication mitoses of cultured human embryonic skin fibroblasts. I report here evidence suggesting that the events involved are separate.

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Authors and Affiliations

  1. Department of Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Tokyo, 113, Japan

    M. S. SASAKI

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SASAKI, M. Sister chromatid exchange and chromatid interchange as possible manifestation of different DNA repair processes. Nature 269, 623–625 (1977). https://doi.org/10.1038/269623a0

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