Abstract
MUCH current interest is focused on the involvement of expressed products of the major histocompatability (H–2) gene complex, especially those associated with the K and D regions of H–2, in inducing cell-mediated immune responses and in permitting recognition and killing by cytoxic thymus-derived lymphocytes (CTL). Observations in many laboratories have led to the generalisation that syngeny between stimulator and target cells at the K and/or D region of H–2 is required for CTL activity to virus-infected cells1–3, minor histocompatibility antigens4, the male H–Y antigen5 and chemically modified syngeneic cells6–9. This study asks three questions related to the geneic restriction of induction and expression of CTL: (1) can non-infectious virus efficiently induce CTL, (2) can non-infectious virus absorbed to target cells render them susceptible to killing by CTL, and (3) can non-infectious virus absorbed onto or chemically linked to cells induce CTL and does using allogeneic or xenogeneic carrier cells affect this induction?
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PALMER, J., LEWANDOWSKI, L. & WATERS, D. Non-infectious virus induces cytotoxic T lymphocytes and binds to target cells to permit their lysis. Nature 269, 595–597 (1977). https://doi.org/10.1038/269595a0
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DOI: https://doi.org/10.1038/269595a0
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