Abstract
THIS study was designed to provide an indirect assessment of the possible role of prostaglandins in retinoid intoxication. If the symptoms of retinoid toxicity are mediated by prostaglandins, an inhibitor of prostaglandin synthesis should ameliorate the symptoms of sublethal intoxication and perhaps even increase the lifespan of mice treated with lethal doses of retinoids. The observations reported here indicate that aspirin can antagonise the toxic effects of retinoic acid.
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HARRISON, S., HIXON, E., BURDESHAW, J. et al. Effect of aspirin administration on retinoic acid toxicity in mice. Nature 269, 511–512 (1977). https://doi.org/10.1038/269511a0
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DOI: https://doi.org/10.1038/269511a0
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