In vitro duplication and ‘cure’ of haemopoietic defects in genetically anaemic mice


SEVERAL types of congenital, genetically determined macrocytic anaemias have been described in mice1–4. These models offer a means of analysing the effects of mutations at defined loci on the ability of haemopoietic tissue to support stem cell proliferation and differentiation and allow studies on intrinsic defects in differentiation capacity of stem cells. But, analysis of these mutations and their implications in relation to pluripotential stem cell control have been hampered by lack of techniques, particularly of in vitro systems, for further defining regulatory interactions between stem cells and the haemopoietic inductive microenvironment. Here we report that the haemopoietic defects seen in W and Steel (S1) mice have been successfully reproduced in vitro.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Russel, E. S. & Bernstein, S. E. in Biology of the Laboratory Mouse, 2nd ed (ed. Green, E. L.) 351 (1966).

  2. 2

    Bernstein, S. E., Russell, E. S. & Keighley, G. Ann. N.Y. Acad. Sci. 149, 475 (1968).

  3. 3

    Bennett, M., Cudkowicz, G., Foster, R. S. & Metcalf, D. J. cell. Physiol. 71, 211 (1968).

  4. 4

    Mayer, T. C. & Green, M. C. Devl Biol. 18, 62 (1968).

  5. 5

    Sutherland, D. J. A., Till, J. E. & McCulloch, E. A. J. cell. Physiol. 75, 267 (1970).

  6. 6

    Dexter, T. M., Allen, T. D. & Lajtha, L. G. J. cell. Physiol. 91, 355 (1977).

  7. 7

    Allen, T. D. & Dexter, T. M. Differentiation 6, 191 (1976).

  8. 8

    Dexter, T. M., Moore, M. A. S. & Sheridan, A. P. C. J. exp. Med. 145, 1612 (1977).

Download references

Author information



Rights and permissions

Reprints and Permissions

About this article

Cite this article

DEXTER, T., MOORE, M. In vitro duplication and ‘cure’ of haemopoietic defects in genetically anaemic mice. Nature 269, 412–414 (1977).

Download citation

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.