Synergistic interaction of testosterone and oestradiol inhibits permatogenesis in rats

Abstract

ONE experimental approach to male contraception has been the systemic administration of androgenic steroids, but treatment has failed sometimes to induce azoospermia1–4. To overcome this difficulty, androgen–progestin formulations have been tested, but they did not inhibit spermatogenesis completely in all treated men5–8. We thought that this variable response was probably due to the relatively weak anti-gonadotropic activity of both androgens and progestins and the difficulty of controlling precisely the dose of steroids administered. We reasoned that azoospermia might be achieved in every male if steroids were administered continuously and at relatively constant rates and if progestins were replaced by a more potent inhibitor of pituitary gonadotropin secretion. We describe here the results of a test of the efficacy of testosterone–oestradiol formulations administered to adult male rats by means of a subdermal sustained release device. Oestradiol was used because, like testosterone, it is a naturally occurring steroid secreted by the mammalian testis9–13 and because it is a potent inhibitor of pituitary gonadotropin secretion14–16.

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EWING, L., DESJARDINS, C., IRBY, D. et al. Synergistic interaction of testosterone and oestradiol inhibits permatogenesis in rats. Nature 269, 409–411 (1977). https://doi.org/10.1038/269409a0

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