Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Gonadotrophin-releasing hormone deficiency in a mutant mouse with hypogonadism


FAMILIAL hypogonadism in man, due to an isolated deficiency of gonadotrophin secretion, has been well documented1–6, but difficult to investigate because of the lack of a suitable animal model4. We report here the genetic and endocrinological background of a mutant strain of mouse in which the testes and ovaries fail to develop postnatally. The primary cause of this seems to be a deficiency in hypothalamic gonadotrophin-releasing hormone (GnRH) with a consequent reduction in pituitary content and circulating levels of luteinising hormone (LH) and follicle-stimulating hormone (FSH). By analogy with the Brattleboro rat (genetic defect in vasopressin synthesis) this mutant should prove useful for studying the synthesis of hypothalamic releasing hormones as well as the role of the hypothalamic–gonadotrophin system in sexual differentiation, puberty, folliculogenesis and spermatogenesis. The mutant has been named hypogonadal, symbol hpg.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Kallman, F. J., Schoenfeld, W. A. & Barrera, S. E. Am. J. ment. Defic. 48, 203–236 (1944).

    Google Scholar 

  2. 2

    Nowakowski, H. & Lenz, W. Rec. Progr. Horm. Res. 17, 53–89 (1961).

    CAS  PubMed  Google Scholar 

  3. 3

    Ewer, R. W. J. clin. Endocr. Metab. 28, 783–788 (1968).

    CAS  Article  Google Scholar 

  4. 4

    Naftolin, F., Harris, G. W. & Bobrow, M. Nature 232, 496–497 (1971).

    ADS  CAS  Article  Google Scholar 

  5. 5

    Santen, R. J. & Paulsen, C. A. J. clin. Endocr. Metab. 36, 47–54 (1973).

    CAS  Article  Google Scholar 

  6. 6

    Boyar, R. M., Wu, R. H. K., Kapen, S., Hellman, L., Weitzman, E. D. & Finkelstein, J. W. J. clin. Endocr. Metab. 43, 1268–1275 (1976).

    CAS  Article  Google Scholar 

  7. 7

    Cattanach, B. M., Williams, C. E. & Bailey, H. Cytogenetics 11, 412–423 (1972).

    CAS  Article  Google Scholar 

  8. 8

    Chester-Jones, I. Br. med. Bull. 11, 156–158 (1955).

    Article  Google Scholar 

  9. 9

    Brown-Grant, K. in Regulation and Control in Living Systems (ed. Kalmus, H.) 176–255 (Wiley, London, 1966).

    Google Scholar 

  10. 10

    Nett, T. M., Akbar, A. M., Niswender, G. D., Hedlund, M. J. & White, W. F. J. clin. Endocr. Metab. 36, 880–885 (1973).

    CAS  Article  Google Scholar 

  11. 11

    Chiappa, S. A. & Fink, G. J. Endocr. 72, 195–210 (1977).

    CAS  Article  Google Scholar 

  12. 12

    Niswender, G. D., Midgley, A. R., Jr, Montoe, S. E. & Reichert, L. E. Jr, Proc. Soc. exp. Biol. Med. 128, 807–811 (1968).

    CAS  Article  Google Scholar 

  13. 13

    Daane, T. A. & Parlow, A. F. Endocrinology 88, 653–663 (1971).

    CAS  Article  Google Scholar 

Download references

Author information



Rights and permissions

Reprints and Permissions

About this article

Cite this article

CATTANACH, B., IDDON, C., CHARLTON, H. et al. Gonadotrophin-releasing hormone deficiency in a mutant mouse with hypogonadism. Nature 269, 338–340 (1977).

Download citation

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing