Orientation of cell-surface antigens in the lipid bilayer of lymphocyte plasma membrane

Abstract

Human HLA-A, B, C and Ia antigens were labelled by lactoperoxidase-catalysed iodination of the inner surface of lymphocyte plasma membrane and thus are transmembrane proteins. In contrast, membrane-bound human IgM and mouse IgM, IgD and Thy-1 antigen were not labelled on the inner membrane surface.

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Walsh, F., Crumpton, M. Orientation of cell-surface antigens in the lipid bilayer of lymphocyte plasma membrane. Nature 269, 307–311 (1977). https://doi.org/10.1038/269307a0

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