Possible regulatory function of acetylcholine receptor in maintenance of retinotectal synapses

Abstract

α-Neurotoxins bind to cholinergic receptor, block transmission, and induce sprouting of retinal terminals in the toad tectum. New connections retain an orderliness that suggests a selective affinity between presynaptic terminals. The results suggest that postsynaptic cells exert a control, associated with receptors, on the growth of presynaptic terminals and on the maintenance of their synaptic connections.

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Freeman, J. Possible regulatory function of acetylcholine receptor in maintenance of retinotectal synapses. Nature 269, 218–222 (1977). https://doi.org/10.1038/269218a0

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