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Receptor that leaves a sour taste in the mouth


The ability to detect taste stimuli results from the activation of taste receptors located in taste-bud cells. There are several gustatory transduction mechanisms, involving membrane receptors, guanine-nucleotide-binding proteins (G proteins), second messengers and ion channels1, but genes encoding taste receptors have not yet been identified. Here we identify a complementary DNA that encodes a receptor for sour tastes.

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Figure 1: Expression and localization of MDEG1.
Figure 2: Expression of MDEG1 in Xenopus oocytes.


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Ugawa, S., Minami, Y., Guo, W. et al. Receptor that leaves a sour taste in the mouth. Nature 395, 555–556 (1998).

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