Abstract
CLASSIC hydatidiform mole is the product of an abnormal pregnancy with grossly swollen chorionic villi, but without an embryo, cord or amniotic membrane. Histologically, the villi are characterised by advanced hyperplasia and anaplasia of the trophoblast, oedema of the stroma and the absence of foetal capillaries1. A malignant change to invasive mole or choriocarcinoma is frequent. The karyotype of the mole is predominantly, if not exclusively, 46,XX. We have made a cytogenetic study of the origin of hydatidiform mole and found that it receives only paternal chromosomes and is therefore androgenetic in origin.
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KAJII, T., OHAMA, K. Androgenetic origin of hydatidiform mole. Nature 268, 633–634 (1977). https://doi.org/10.1038/268633a0
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DOI: https://doi.org/10.1038/268633a0
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