Nerve growth factor-induced increase in electrical excitability and acetylcholine sensitivity of a rat pheochromocytoma cell line

Abstract

A cloned line of rat pheochromocytoma cells (PC12) which responds to nerve growth factor (NGF) by cessation of division and extension of neurone-like processes, is shown to develop electrical excitability and greatly increased acetylcholine sensitivity in the presence of NGF. This implies that NGF influences the physiological differentiation of certain neural crest derivatives.

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Dichter, M., Tischler, A. & Greene, L. Nerve growth factor-induced increase in electrical excitability and acetylcholine sensitivity of a rat pheochromocytoma cell line. Nature 268, 501–504 (1977). https://doi.org/10.1038/268501a0

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