Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Reduced β-adrenergic receptor concentrations in ageing man

Nature volume 267, pages 856–858 (1977)Cite this article

Abstract

CONCENTRATIONS of certain hormone receptors are known to be reduced during ageing in several animal species1–4. Most relevant work, however, has been limited to intracellular hormone receptors such as those for steroids, and less is known about changes in cell surface receptors, including those for catecholamines. We have measured the concentration of β-adrenergic receptors in crude membrane fractions of mononuclear cells from human subjects of various ages. Receptor affinities for (—)3H-dihydroal-prenolol were esentially the same for all subjects. But a significant decrease in receptor concentration was observed in cells from older individuals.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Roth, G. S. & Livingston, J. N., Endocrinology 99, 831–839 (1976).

    Article  CAS  PubMed  Google Scholar 

  2. Shain, S. A., Boesel, R. W. & Axelrod, L. R., Archs Biochem. Biophys. 167, 247–263 (1973).

    Article  Google Scholar 

  3. Singer, S., Ito, H. & Litwack, G., Int. J. Biochem. 4, 569–573 (1973).

    Article  CAS  Google Scholar 

  4. Nelson, J. F. et al. Abstr. 29th A. Meeting Gerontol. Soc. 34 (1976).

  5. Böyum, A., Scand. J. clin. Invest. 21, Suppl. 97, 77–89(1968).

    Article  Google Scholar 

  6. Williams, L. T., Snyderman, R. & Lefkowitz, R. J., J. clin. Invest. 57, 149–155 (1976).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Yam, L. T., Li, C. Y. & Crosby, W. H., Am. J. clin. Path. 55, 283–290 (1971).

    Article  CAS  PubMed  Google Scholar 

  8. Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J., J. biol. Chem. 193, 265–275 (1951).

    PubMed  CAS  Google Scholar 

  9. Kanungo, M. S., Patnaik, S. K. & Koul, O., Nature 253, 366–367 (1975).

    Article  ADS  CAS  PubMed  Google Scholar 

  10. Moudgil, V. K. & Kanungo, M. S., Biochem. biophys. Res. Commun. 52, 725–730 (1973).

    Article  CAS  PubMed  Google Scholar 

  11. Roth, G. S., Biochim. biophys. Acta 399, 145–156 (1975).

    Article  CAS  PubMed  Google Scholar 

  12. Freeman, C., Karoly, K. & Adelman, R. C., Biochem. biophys. Res. Commun. 54, 1573–1580 (1973).

    Article  CAS  PubMed  Google Scholar 

  13. Livingston, J. N., Cuatrecasas, P. & Lockwood, D. H., J. Lipid Res. 15, 26–32 (1974).

    PubMed  CAS  Google Scholar 

  14. Rosenbloom, A., Goldstein, S. & Yip, C., Abstr. 5th int. Cong. Endocr., Hamburg, 261 (1976).

  15. Itoh, H., Orimo, H. & Shimada, H., Abstr. 5th int. Cong. Endocr., Hamburg, 261 (1976).

  16. Augener, W., Cohnen, G., Reuter, A. & Brittinger, E., Lancet i, 1164 (1974).

    Article  Google Scholar 

  17. Weksler, M. E. & Hutteroth, T. H., J. clin. Invest. 53, 99–104 (1974).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Diaz-Jouanen, E., Williams, R. C. Jr & Strickland, R. G., Lancet i, 688–689 (1975).

    Article  Google Scholar 

  19. Mukherjee, C., Caron, M. G. & Lefkowitz, R. J., Proc. natn. Acad. Sci. 72, 1945–1949 (1975).

    Article  ADS  CAS  Google Scholar 

  20. Ziegler, M. G., Lake, C. R. & Kopin, I. J., Nature 261, 333–335 (1976).

    Article  ADS  CAS  PubMed  Google Scholar 

  21. Fleisch, J. H., Maling, H. M. & Brodie, B. B., Circulat. Res. 26, 151–162 (1970).

    Article  CAS  PubMed  Google Scholar 

  22. Berger, M., Preiss, H., Hesse-Wortmann, C. & Gries, F., Gerontologia 17, 312–322 (1971).

    Article  CAS  PubMed  Google Scholar 

  23. Lakatta, E. G., Gerstenblith, G., Angell, C. S., Shock, N. W. & Weisfeldt, M. L., Circulat. Res. 36, 262–269 (1975).

    Article  CAS  PubMed  Google Scholar 

  24. Yin, F. C. et al. Circulation 54, Suppl. II, 167 (1976).

    Article  Google Scholar 

  25. Bourne, H. R. et al. Science 184, 19–28 (1974).

    Article  ADS  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Gerontology Research Center, National Institute on Aging, Baltimore City Hospitals, Baltimore, Maryland, 21224

    D. D. SCHOCKEN & G. S. ROTH

Authors
  1. D. D. SCHOCKEN
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. S. ROTH
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

SCHOCKEN, D., ROTH, G. Reduced β-adrenergic receptor concentrations in ageing man. Nature 267, 856–858 (1977). https://doi.org/10.1038/267856a0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/267856a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing