Abstract
WE have sequenced the DNA region immediately preceding the structural gene for the 5S ribosomal RNA of yeast (Saccharomyces cerevisiae). Since the 5S RNA, a component of the larger ribosomal subunit, has a 5′ triphosphate1,2, this molecule is likely to be the direct product of the gene, unmodified by maturation at the 5′ end. Thus the DNA sequence immediately before this region must contain the recognition sequences where the RNA polymerase binds to begin synthesis, that is, this sequence must represent a eukaryotic promoter.
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MAXAM, A., TIZARD, R., SKRYABIN, K. et al. Promoter region for yeast 5S ribosomal RNA. Nature 267, 643–645 (1977). https://doi.org/10.1038/267643a0
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DOI: https://doi.org/10.1038/267643a0
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