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Effects of PGD2 on canine renal function

Nature volume 267, pages 628–630 (1977)Cite this article

Abstract

IN many tissues, especially the mammalian kidney, prostaglandin D2 (PGD2) is a significant product in the metabolism of the bisenoic prostaglandin endoperoxides1,2. PGD2 was originally reported to have negligible biological activity1; but, subsequent workers noted that it produces vascular effects in several species3,4. Although the effects in the kidney of the precursor, arachidonic acid, and other prostaglandins (PGs)5–7 have attracted much interest, the effects of PGD2 have received little attention. Since PGD2 may be an important product of arachidonate metabolism in the kidney8,9, the renal response to an infusion of PGD2 in the dog was examined and compared with the response to an infusion of PGE2. Whereas both PGs produced an increase in renal blood flow, only PGE2 caused a diuresis and natriuresis. This suggests that PGD2 in the kidney is primarily involved in the control of renal haemodynamics, and does not participate in the regulation of fluid and electrolyte excretion.

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Authors and Affiliations

  1. Departments of Physiology and Biophysics and Medicine, Schools of Medicine and Dentistry, Georgetown University, Washington, DC, 20007

    P. MICHAEL BOLGER, GILBERT M. EISNER, P. TEREZ SHEA, PETER W. RAMWELL & LAWRENCE M. SLOTKOFF

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  1. P. MICHAEL BOLGER
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  2. GILBERT M. EISNER
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  3. P. TEREZ SHEA
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  4. PETER W. RAMWELL
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  5. LAWRENCE M. SLOTKOFF
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BOLGER, P., EISNER, G., SHEA, P. et al. Effects of PGD2 on canine renal function. Nature 267, 628–630 (1977). https://doi.org/10.1038/267628a0

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