Abstract
THE HLA region in man has been assigned to the short arm of chromosome 6 (ref. 1). Close genetic linkage has been shown between HLA and genes involved in the synthesis of the second2–3 and fourth4 components of complement as well as structural variation of the glycinerich B-glycoprotein (GBG or Bf)5. Two enzymes, phosphoglucomutase-3 (PGM3)6–7 and glyoxalase I (GLO)1,8–12, and two blood group antigens, Chido13 and Rodgers1, have been shown to be in this linkage group. Here we describe a family with an intra-HLA recombinant sibling and an HLA–GLO recombinant sibling. The mother is heterozygous at the HLA-A and -B loci, homozygous for HLA-DW2, and heterozygous at the GLO locus, thus permitting identification of an HLA–GLO recombinant in one of her children. Our investigations suggest that the locus for GLO polymorphism is on the centromeric side of HLA-B on the short arm of chromosome 6.
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References
Baltimore Conference (1975), International Workshop of Human Gene Mapping in Birth Defects: Original Article Series XII, 7 (National Foundation, New York 1976).
Fu, S. M., Kunkel, H. G., Brusman, H. P., Allen, F. H., Jr. & Fotino, M. j. exp. Med. 140, 1108–1111 (1974).
Friend, P. S., Handwerger, G. S., Kim, Y., Michael, A. F. & Yunis, E. J. Immunogenetics 2, 569–576 (1975).
Aarhus Conference (1975), 6th International Histocompatibihty Workshop. Histocompatibility Testing 1975 (ed. Kissmeyer-Nielsen, F.) (Munksgaard, Copenhagen 1975).
Allen, F. H. Jr Vox Sang. 27, 382–384 (1974).
Lamm, L. U., Svejgaard, A. & Kissmeyer-Neilsen, F. Nature new Biol. 231, 109–110 (1971).
Lamm, L. U. et al. Tissue Antigens 2, 205–214 (1972).
Mayr, W. R., Mayr, D., Kompf, J., Bissbort, S. & Ritter, H. Humangenetik 31 241–242 (1976).
Weitkamp, L. R. Tissue Antigens 7, 273–279 (1976).
Pretorius, A. M. G., Scholz, S., Kuntz, B. & Albert, E. D. Immunogenetics (in the press).
Kompf, J. & Bissbort S. & Ritter H. Humangenetik 28, 249–251 (1975).
Kompf, J. & Bissbort, S. Humangenetik 28, 175–176 (1976).
Middleton, J. et al. Tissue Antigens 4, 366–373 (1974).
O'Leary, J., Reinsmoen, N. & Yunis, E. J. in Manual of Clinical Immunology 820–832 (1976).
Dupont, B. et al. proc. natn. Acad. Sci. U.S.A. 71, 52–56 (1974).
Yunis, E. J. & Amos, D. B. Proc. natn. Acad. Sci. U.S.A. 68, 3031–3035 (1975).
Harrison, M. R. & Paul, W. E. J. exp. Med 138, 1602–1607 (1973).
Alper, C. A., Boenisch, T. & Watson, L. J. exp. Med. 135, 68–80 (1972).
Kompf, J., Bissbort, S., Gussman, S. & Ritter, H. Humangenetik 27, 141–143 (1975).
Giblett, E. R. in Generic Markers in Human Blood 438 (Blackwell, Oxford, 1969).
Amos, B. D. & Pool, P. in Manual of Clinical Immunology (eds Rose, N. R. & Friedman, H.) 797–807 (Washington DC, 1976).
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REINSMOEN, N., FRIEND, P., MILLER, W. et al. Inheritance of recombinant HLA-GLO haplotype suggesting the gene sequence. Nature 267, 276–278 (1977). https://doi.org/10.1038/267276a0
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DOI: https://doi.org/10.1038/267276a0
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