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Inheritance of recombinant HLA-GLO haplotype suggesting the gene sequence

Abstract

THE HLA region in man has been assigned to the short arm of chromosome 6 (ref. 1). Close genetic linkage has been shown between HLA and genes involved in the synthesis of the second2–3 and fourth4 components of complement as well as structural variation of the glycinerich B-glycoprotein (GBG or Bf)5. Two enzymes, phosphoglucomutase-3 (PGM3)6–7 and glyoxalase I (GLO)1,8–12, and two blood group antigens, Chido13 and Rodgers1, have been shown to be in this linkage group. Here we describe a family with an intra-HLA recombinant sibling and an HLA–GLO recombinant sibling. The mother is heterozygous at the HLA-A and -B loci, homozygous for HLA-DW2, and heterozygous at the GLO locus, thus permitting identification of an HLA–GLO recombinant in one of her children. Our investigations suggest that the locus for GLO polymorphism is on the centromeric side of HLA-B on the short arm of chromosome 6.

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REINSMOEN, N., FRIEND, P., MILLER, W. et al. Inheritance of recombinant HLA-GLO haplotype suggesting the gene sequence. Nature 267, 276–278 (1977). https://doi.org/10.1038/267276a0

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