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X-ray study of the lithium complex of NAD+

Nature volume 267, pages 225–229 (1977)Cite this article

Abstract

The Li+·NAD+ complex exists as a ‘dimer’ of two molecules arranged head-to-tail with Li+ coordinated tetrahedrally to adenine N(7) and three pyrophosphate oxygens. Adenine is stacked intermolecularly on nicotinamide. The conformation of NAD+ is ‘extended’ and similar to that found in holoenzyme complexes. This is in contrast to the ‘folded’ structure proposed from spectroscopic studies.

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Author notes

  1. K. Mühlegger & G. Weimann

    Present address: Boehringer-Mannheim, Biochemica-Werk Tutzing, 8132, Tutzing, Germany

Authors and Affiliations

  1. Abteilung Chemie, Max-Planck-Institut für experimentelle Medizin, Hermann-Rein-Str. 3, D-34, Göttingen, Germany

    W. Saenger, B. S. Reddy, K. Mühlegger & G. Weimann

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  2. B. S. Reddy
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  3. K. Mühlegger
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  4. G. Weimann
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Saenger, W., Reddy, B., Mühlegger, K. et al. X-ray study of the lithium complex of NAD+. Nature 267, 225–229 (1977). https://doi.org/10.1038/267225a0

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