Abstract
In vitro study of nerve cell differentiation has been primarily concentrated on the examination of cell lines that, at least partially, express terminal steps of differentiation. The isolation and characterisation of precursor populations would be an aid to further understanding of nerve cell differentiation. I present here evidence for a clonal line of such a nerve cell precursor type which, after in vivo passage, is able to give distinct neuronal phenotypes. These phenotypes are potentially lineage related, and show qualitative differences in the expression of their hypothalamic neuronal function.
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VITRY, F. Growth and differentiation of a primitive nervous cell line after in vivo transplantation into syngeneic mice. Nature 267, 48–50 (1977). https://doi.org/10.1038/267048a0
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DOI: https://doi.org/10.1038/267048a0
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