Letter | Published:

Neonatally tolerant mice fail to react against virus-infected tolerated cells

Naturevolume 266pages837839 (1977) | Download Citation

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Abstract

IN mice, immune effector functions mediated by thymus-derived lymphocytes (T cells) are restricted by the major histocompatibility (H–2) gene complex (see ref. 1 for review). Thus, virus-stimulated cytotoxic T cells are specific for both viral antigen(s) and self-cell-surface structures coded in the K or D region of H–2 (refs 2, 3). Two general hypotheses have been proposed to explain H–2 restriction2–5. First, T cells possess two independently, clonally expressed, but linked receptors, one for the foreign antigenic determinant and one for the relevant self-marker (dual receptor model); second, T cells have a single clonally distributed receptor for a complex of foreign antigen plus self or for virally altered self-markers (altered self model). To date no conclusive proof exists for one hypothesis or the other. The altered self model is the simpler concept of the two; on the other hand, the fact that cytolytic interactions against minor histocompatiblity antigens are H–2 restricted and that the idiotypic determinants of T cell-receptors are identical with those of immunoglobulins of the same specificity6–8 are probably more compatible with a dual receptor.

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References

  1. 1

    Munro, A. & Bright, S. Nature 264, 145–152 (1976).

  2. 2

    Zinkernagel, R. M. & Doherty, P. C. Nature 248, 701–702 (1974).

  3. 3

    Blanden, R. V. et al. Nature 254, 269–270 (1975).

  4. 4

    Doherty, P. C., Blanden, R. V. & Zinkernagel, R. M. Transplant. Rev. 29, 89–124 (1976).

  5. 5

    Zinkernagel, R. M. & Doherty, P. C. Nature 251, 547–548 (1974); J. exp. Med. 141, 1427–1436 (1975).

  6. 6

    Ramseier, H. R. & Lindenmann, J. Transplant. Rev. 10, 57–96 (1972).

  7. 7

    Binz, H., Kimura, A. & Wigzell, H. Scand. J. Immun. 4, 413–420 (1975).

  8. 8

    Eichmann, K. Immunogenetics 2, 491–506 (1975).

  9. 9

    Pfizenmaier, K., Starzinski-Powitz, A., Rotd, H., Röllinghoff, M. & Wagner, H. J. exp. Med. 143, 599–604 (1976).

  10. 10

    Zinkernagel, R. M. Nature 261, 139–141 (1976); J. exp. Med. 144, 933–945 (1976).

  11. 11

    Von Boehmer, H. & Haas, W. Nature 261, 141–142 (1976).

  12. 12

    Billingham, R. E., Brent, L. & Medawar, P. B. Phil. Trans. R. Soc. B 239, 357–375 (1956).

  13. 13

    Klein, J. Biology of the Mouse Histocompatibility–2 Complex (Springer, Berlin, 1975).

  14. 14

    Callahan, G. N., Ferrone, S., Poulik, M. D., Reisfeld, R. A. & Klein, J. J. Immun. 117, 1351–1355 (1976).

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Affiliations

  1. Department of Cellular and Developmental Immunology, Scripps Clinic and Research Foundation, La Jolla, California, 92037

    • R. M. ZINKERNAGEL
  2. Department of Molecular Immunology, Scripps Clinic and Research Foundation, La Jolla, California, 92037

    • G. N. CALLAHAN
  3. Department of Cell Biology, Southwestern Medical School, Dallas, Texas

    • J. W. STREILEIN
  4. Department of Microbiology, Southwestern Medical School, Dallas, Texas

    • J. KLEIN

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https://doi.org/10.1038/266837a0

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