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Correlation between the X-ray structure of melanostatin and its conformation in solution

Naturevolume 266pages746748 (1977) | Download Citation



THE establishment of correlations between solid-state (for example, X-ray) conformations and conformations in solution (monitored by spectroscopic methods such as nuclear magnetic resonance (NMR)) is essential for the understanding of structure–function relationships in biologically active molecules. The relative functional importance of static and dynamic structures is of particular interest for peptide hormones which reach their site(s) of action on the receptor via a fluid medium. We describe here a comparative study of melanostatin (Pro–Leu–Gly–NH2) which acts as a melanocyte stimulating hormone release-inhibiting factor1.

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  1. 1

    Nair, R. M. G., Kastin, A. J. & Schally, A. V. Biochem. biophys. Res. Commun. 43, 1376–1381 (1971).

  2. 2

    Reed, L. L. & Johnson, P. L. J. Am. chem. Soc. 95, 7523–7524 (1973).

  3. 3

    Ralston, E., De Coen, J. L. & Walter, R. Proc. natn. Acad. Sci. U.S.A. 71, 1142–1144 (1974).

  4. 4

    Walter, R., Bernal, I. & Johnson, L. F. in Chemistry and Biology of Peptides (ed. Meinhofer, J.) 131–135 (Ann Arbor, Ann Arbor, Michigan, 1975).

  5. 5

    Higashigima, T., Tasumi, M. & Miyazawa, T. FEBS Lett. 57, 175–178 (1975).

  6. 6

    Deslauriers, R., Walter, R. & Smith, I. C. P. FEBS Lett. 37, 27–32 (1973).

  7. 7

    Somorjai, R. L. & Deslauriers, R. J. Am. Chem. Soc. 98, 6460–6467 (1976).

  8. 8

    Deslauriers, R., Ralston, E. & Somorjai, R. L. J. molec. Biol. (in the press).

  9. 9

    Void, R. L., Waugh, J. S., Klein, M. P. & Phelps, D. E. J. chem. Phys. 55, 3604 (1971).

  10. 10

    Noggle, J. L. & Schirmer, R. E. in The Nuclear Overhauser Effect—Chemical Applications (Academic, New York, 1971).

  11. 11

    Quantum Chemistry Exchange Program 178, modified by W. M. Murphy.

  12. 12

    Johnson, C. K., Oak Ridge National Laboratory Publication, ORNL-3794, Revised UC-4-Chemistry (1965).

  13. 13

    Deslauriers, R., Smith, I. C. P. & Walter, R. J. biol. Chem. 249, 7006–7010 (1974).

  14. 14

    Levy, G. & Nelson, G. L. Carbon-13 Nuclear Magnetic Resonance for Organic Chemists (Wiley-Interscience, New York, 1972).

  15. 15

    Deslauriers, R. & Somorjai, R. L. J. Am. chem. Soc. 98, 1931–1939 (1976).

  16. 16

    Flory, D. J., Statistical Mechanics of Chain Molecules 152 (Wiley-Interscience, New York, 1969).

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  1. ROXANNE DESLAURIERS: Division of Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada KIA 0R6

  2. R. L. SOMORJAI: Division of Chemistry, National Research Council of Canada, Ottawa, Ontario, Canada KIA 0R6


  1. >‡Laboratoire de Chimie Biologique, Université Libre de Bruxelles, 1640 Rhode St., Genèse, Belgium



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