Letter | Published:

Comparable complex rearrangements involving 8;21 and 9;22 translocations in leukaemia

Naturevolume 266pages744745 (1977) | Download Citation

Subjects

Abstract

FOR many years chromosomal abnormalities in tumours seemed to be so variable that it seemed most reasonable to view them as epiphenomena. But banding techniques have revealed non-random chromosomal abnormalities in several human and mammalian malignancies. The observation of relatively consistent translocations in several types of leu kaemia and lymphoma lends credence to Boveri's hypothesis1 that chromosomal alterations are among the fundamental changes that result in malignancy. For example, the Philadelphia (Ph1) translocation2 is observed in 85–90% of patients with chronic myelogenous leukaemia (CML), and the 8;21 translocation is observed in 10–15% of patients with acute myelocytic leukaemia (AML)3,4. We report here that, when more complex structural changes occur, com parable patterns of rearrangements are found for both the 9;22 and the 8;21 translocations. This provides further sup port for Boveri's hypothesis.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Boveri, T. Beitr. Pathol. 14, 249 (1912).

  2. 2

    Rowley, J. D. Nature 243, 290–293 (1973).

  3. 3

    Rowley, J. D. Ann. Genet. 16, 109–112 (1973).

  4. 4

    Sakurai, M., Oshimura, M., Kakati, S. & Sandberg, A. A. Lancet ii, 227–228 (1974).

  5. 5

    Rowley, J. D. Lancet ii, 835–836 (1974).

  6. 6

    Rowley, J. D. Ptoc. Sixth int. Cong. Human Genet. (Excerpta Medica, in the press).

Download references

Author information

Affiliations

  1. Department of Medicine and Franklin McLean Memorial Research Institute, University of Chicago, Chicago, Illinois, 60637

    • VALERIE LINDGREN
    •  & JANET D. ROWLEY

Authors

  1. Search for VALERIE LINDGREN in:

  2. Search for JANET D. ROWLEY in:

About this article

Publication history

Received

Accepted

Issue Date

DOI

https://doi.org/10.1038/266744a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.