Letter | Published:

Heterosynaptic depression: a postsynaptic correlate of long-term potentiation

Naturevolume 266pages737739 (1977) | Download Citation

Subjects

Abstract

BRIEF trains of electrical stimulation delivered to any one of several hippocampal pathways often result in immediate and long-lasting enhancement of subsequent postsynaptic responses elicited by that pathway1–5. The unusual characteristics of these effects suggest that theories of long-term potentiation (specifically changes in transmitter release by the presynaptic terminal) which have evolved from work on invertebrate and neuromusclar preparations may not be appropriate to explain synaptic plasticity in hippocampus. We report here the results of experiments intended to examine the postsynaptic consequences of repetitive stimulation. We found that potentiation of one afferent tended to depress the target cell's responses to a second test input.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Lomo, T. Acta physiol. scand. 68, Suppl. 277, 128 (1966).

  2. 2

    Bliss, T. V. P. & Lomo, T. J. Physiol., Lond. 232, 331–356 (1973).

  3. 3

    Bliss, T. V. P. & Gardner-Medwin, A. R. J. Physiol., Lond. 232, 357–374 (1973).

  4. 4

    Schwartzkroin, P. & Webster, K. Brain Res. 89, 107–119 (1975).

  5. 5

    Deadwyler, S., Gribkoff, V., Cotman, C. & Lynch, G. Brain Res. Bull. 1, 1–7 (1976).

  6. 6

    Lynch, G., Smith, R., Browning, M. & Deadwyler, S. Advances in Neurology (ed. Kreutzberg, G.) 12, 297–313 (Raven, New York, 1975).

  7. 7

    Spencer, H., Gribkoff, V., Cotman, C. & Lynch, G. Brain Res. 105, 471–481 (1976).

  8. 8

    Blackstead, T. J. comp. Neurol. 105, 417–538 (1956).

  9. 9

    Mosko, S., Lynch, G. & Cotman, C. J. comp. Neurol. 152, 163–174 (1973).

  10. 10

    Andersen, P., Bliss, T. V. P. & Skrede, K. Expl. Brain Res. 13, 208–221 (1971).

  11. 11

    Lynch, G., Gribkoff, V. & Deadwyler, S. Nature 263, 251 (1976).

Download references

Author information

Affiliations

  1. Department of Psychobiology, University of California, Irvine, California, 92717

    • G. S. LYNCH
    • , T. DUNWIDDIE
    •  & V. GRIBKOFF

Authors

  1. Search for G. S. LYNCH in:

  2. Search for T. DUNWIDDIE in:

  3. Search for V. GRIBKOFF in:

About this article

Publication history

Received

Accepted

Issue Date

DOI

https://doi.org/10.1038/266737a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.