Abstract
INTEREST in the regulation of T-cell-mediated cytotoxicity by the major histocompatibility complex (MHC) genes stems from the discovery of (1) an H–2 restriction of T-cell-mediated cytotoxicity, that is sensitising cells, effector cells and target cells need to be syngeneic at the H–2 locus, especially at the D and or K regions of the MHC1–5 for effective killing and (2) inhibition of T-cell-mediated cytotoxic reactions against syngeneic tumours with alloantibodies to H–2 antigens specific for the tumour cells6,7. Different origins have been proposed for the tumour-associated antigens (TAA), and the most favourable model is a modified H–2 antigen or an adaptor–antigen complex4–7. This issue has important implications for tumour immunology, and so we have evaluated the validity of the inhibition of cytotoxicity by serum at the effector phase level; investigated afferent interference by serum of the cell-mediated cytotoxic response, and studied the inhibition of cell-mediated cytotoxic reactions with soluble antigens. We report here that there is a lack of H–2 restriction of T-cell-mediated cytotoxicity to TAA, and that TAA seems to differ from H–2 antigens. This implies that T-cell recognition is not entirely regulated by the MHC genes.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Zinkernagel, R. M. & Doherty, P. C. Nature 248, 701–702 (1974).
Blanden, R. Y. et al. Nature 254, 269–270 (1975).
Koszinowski, U. & Thomssen, R. Eur. J. Immun. 5, 245–251 (1975).
Gomard, E., Duprez, V., Henin, Y. & Levy, J. P. Nature 260, 707–709 (1976).
Blank, K. J., Freedman, H. A. & Lilly, F. Nature 260, 250–252 (1976).
Germain, R. N., Dorf, M. E. & Benacerraf, B. J. exp. Med. 142, 1023–1028 (1975).
Schrader, J. W., Cunningham, B. A. & Edelman, G. M. Proc. natn. Acad. Sci U.S.A. 72, 5066–5070 (1975).
Ting, C. C., Bushar, G. S., Rodrigues, D. & Herberman, R. B. J. Immun. 115, 1351–1356 (1975).
Glynn, J. P., McCoy, J. L. & Fefer, A. Cancer Res. 28, 434–439 (1968).
Ting, C. C. & Bonnard, G. D. J. Immun. 116, 1419–1425 (1976).
Ting, C. C., Rodrigues, D., Busbar, G. S. & Herberman, R. B. J. Immun. 116, 236–243 (1976).
Ting, C. C., Kirchner, H., Rodrigues, D., Park, J. Y. & Herberman, R. B. J. Immun. 116, 244–252 (1976).
Freedman, H. A. & Lilly, F. J. exp. Med. 142, 212–223 (1975).
Ting, C. C. & Law, L. W. J. Immun. (in the press).
Sparks, F. C., Ting, C. C., Hammond, W. G. & Herberman, R. B. J. Immun. 102, 842–847 (1969).
Ting, C. C. & Herberman, R. B. Nature 257, 801–802 (1975).
Trinchieri, G., Aden, D. P. & Knowles, B. B. Nature 261, 312–314 (1976).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
TING, CC., ROGERS, M. Inhibition by sera and soluble antigens of T-cell-mediated cytotoxicity against leukaemia-associated antigens. Nature 266, 727–729 (1977). https://doi.org/10.1038/266727a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/266727a0
This article is cited by
-
The spatial relationship of the viral and H-2 antigens recognized by anti-viral CTLs
Immunogenetics (1980)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
