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Carcinogen-induced mutations at two separate genetic loci are not enhanced by leukaemia virus infection

Naturevolume 266pages548550 (1977) | Download Citation



THE interrelationship between cellular mutagenesis and carcinogenesis has been studied primarily by measuring these two events in separate target systems using chemicals with known biological activity1. Most carcinogens, in appropriate experimental conditions, induce mutations in prokaryotic2 and eukaryotic3 test systems. There are, however, some well known exceptions. Some nucleic acid base analogues and the acridines, which are excellent mutagens, are not known to be carcinogenic in vivo. Similarly, asbestoid minerals and some metallic salts which are potent carcinogens do not produce gene mutation. We describe here a study of the relationship between transformation and mutation with different experimental approaches, and show that carcinogen-induced mutations at two separate genetic loci are not enhanced by leukaemia virus infection.

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  1. Microbiological Associates, 5221 River Road, Bethesda, Maryland, 20016

    • , KAMALA J. PANT


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