Letter | Published:

Carcinogen-induced mutations at two separate genetic loci are not enhanced by leukaemia virus infection

Naturevolume 266pages548550 (1977) | Download Citation

Subjects

Abstract

THE interrelationship between cellular mutagenesis and carcinogenesis has been studied primarily by measuring these two events in separate target systems using chemicals with known biological activity1. Most carcinogens, in appropriate experimental conditions, induce mutations in prokaryotic2 and eukaryotic3 test systems. There are, however, some well known exceptions. Some nucleic acid base analogues and the acridines, which are excellent mutagens, are not known to be carcinogenic in vivo. Similarly, asbestoid minerals and some metallic salts which are potent carcinogens do not produce gene mutation. We describe here a study of the relationship between transformation and mutation with different experimental approaches, and show that carcinogen-induced mutations at two separate genetic loci are not enhanced by leukaemia virus infection.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Bartsch, H. Mutat. Res. 38, 177–189 (1976).

  2. 2

    McCann, J., Choi, E., Yamasaki, E. & Ames, B. Proc. natn. Acad. Sci. U.S.A. 72, 5135–5139 (1975).

  3. 3

    Huberman, E., Sachs, L., Yang, S. K. & Gelboin, H. V. Proc. natn. Acad. Sci. U.S.A. 73, 607–611 (1976).

  4. 4

    Freeman, A. E. et al. J. natn. Cancer Inst. 51, 799–808 (1973).

  5. 5

    Price, P. J., Suk, W. A. & Freeman, A. E. Science 117, 1003–1006 (1973).

  6. 6

    Price, P. J. et al. Proc. Soc. exp. Biol. Med. 150, 650–653 (1975).

  7. 7

    Sarma, P. S. et al. J. natn. Cancer Inst. 54, 1355–1359 (1975).

  8. 8

    Mishra, N. K. & Ryan, W. L. Int. J. Cancer 11, 123–130 (1973).

  9. 9

    Mishra, N. K., Pant, K. J., Thomas, F. O. & Price, P. J. Int. J. Cancer 18, 852–858 (1976).

  10. 10

    Price, P. J., Auletta, A. E., King, M. P., Hugunin, P. M. & Heubner, R. J. In Vitro 12, 595–598 (1976).

  11. 11

    Waters, R., Mishra, N. K., Bouck, N., diMayorca, G. & Regan, J. D. Proc. natn. Acad. Sci. U.S.A. 74, 238–242 (1977).

  12. 12

    Pearson, E. S. & Hartley, H. O. Table 36 in Biometrika Tables for Statistician (Cambridge University Press, London, 1954).

  13. 13

    Clive, D. & Spector, J. F. F. Mutat. Res. 31, 17–29 (1975).

  14. 14

    Baker, R. M. et al. Cell 1, 1–12 (1974).

  15. 15

    Mondal, S., Brankow, D. W. & Heidelburger, C. Cancer Res. 36, 225–226 (1976).

  16. 16

    Trosko, J. E., Chang, C., Yott, L. D. & Chu, E. Y. Cancer Res. 37, 188–193 (1977).

Download references

Author information

Affiliations

  1. Microbiological Associates, 5221 River Road, Bethesda, Maryland, 20016

    • NIRMAL K. MISHRA
    • , KAMALA J. PANT
    • , CAROLYN M. WILSON
    •  & FRANCINA O. THOMAS

Authors

  1. Search for NIRMAL K. MISHRA in:

  2. Search for KAMALA J. PANT in:

  3. Search for CAROLYN M. WILSON in:

  4. Search for FRANCINA O. THOMAS in:

About this article

Publication history

Received

Accepted

Issue Date

DOI

https://doi.org/10.1038/266548a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.