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Selective cellular natural killing against human leukaemic T cells and thymus

Naturevolume 266pages546548 (1977) | Download Citation

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Abstract

NATURALLY-occurring antibodies against thymocytes, certain leukaemias and other tumour cells have been observed in various species including man1,2. In addition, natural cellular immunity—also known as cellular natural killing (CNK)—has been described recently in man3–5 and in mice6–9. The possible role of CNK in tumour surveillance and the nature of the effector cells are presently subject to extensive research. Relatively little is known, however, about the nature and sensitivity of the target cells in relation to CNK. We report here that human leukaemic T cells and human thymocytes are highly sensitive to CNK by normal human peripheral blood and that B cell lines are relatively insensitive. The response seems to be unrelated to HLA and expressed variably by different individuals.

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Affiliations

  1. Division of Immunology, Department of Microbiology and Immunology, Duke University Medical Center, Durham, North Carolina, 27710

    • AKIRA ONO
    • , D. BERNARD AMOS
    •  & HILLEL S. KOREN

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https://doi.org/10.1038/266546a0

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