Letter | Published:

Human LD antigens are present on xenogeneic cells

Naturevolume 266pages540542 (1977) | Download Citation

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Abstract

THE mixed leukocyte culture (MLC) reaction is largely a measure of specific responsiveness of thymus-derived lymphocytes to foreign allogeneic and xenogeneic major histocompatibility complex (MHC) controlled LD antigens1. In view of the remarkable primary structure homologies of MHC-controlled SD antigens between humans and mice2, we have investigated whether MHC LD antigens have also been conserved in evolution by studying the extent of LD sharing between different species. Using the primed lymphocyte typing (PLT) test, we have found extensive sharing of LD antigens between humans and monkeys, and less, but still significant, sharing between humans and dogs and humans and cattle. In no case was there evidence that mouse LD antigens were shared with those of humans.

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Affiliations

  1. Immunobiology Research Center and Departments of Medical Genetics and Surgery, The University of Wisconsin, Madison, Wisconsin, 53706

    • JOANNE MARTINIS
    •  & FRITZ H. BACH

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https://doi.org/10.1038/266540a0

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