Abstract
WE try here to establish a link between a motility phenomenon in animal cells and the presence of the so-called ‘large external transformation-sensitive (LETS)’ protein on the surface of the cells. Through studies of this protein a new and still puzzling aspect of animal cell surfaces became apparent. Originally discovered as a major surface glycoprotein of molecular weight 220,000–250,000 which disappeared on cell transformation (for review, see ref. 1), it has since become quite likely that various differently named surface glycoproteins—galactoprotein a (ref. 2), fibroblast surface antigen3, Zeta protein4, ‘cell-surface protein’ (CSP)5, and ‘cold-insoluble globulin’ (CIG)6–8—which were studied independently by different investigators, are identical to or at least very closely related to LETS protein.
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ALBRECHT-BUEHLER, G., CHEN, L. Local inhibition of centripetal particle transport where LETS protein patterns appear on 3T3 cells. Nature 266, 454–456 (1977). https://doi.org/10.1038/266454a0
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DOI: https://doi.org/10.1038/266454a0
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