Abstract
KNITTLE and Hirsch1 reported that varying the calorific intake of newborn rats by manipulating litter size during the 21-d suckling period followed by allowing free access to food after weaning caused the rats from small litters to have more adipocytes in the epididymal depot than rats from large litters. Hirsch and Han2 reported that marked changes in depot size induced by starvation or experimental obesity produced no change in total number of adipocytes in the epididymal and retroperitoneal depots of rats even when these alterations occurred as early as 6 weeks of age. These and other studies3–5 suggest that it is the calorific intake between birth and weaning rather than later in life that plays the important role in establishing the cellularity of the adipose tissue depots of the adult. But we report here data which indicate that a reduction in food intake can markedly influence the number of adipocytes in the depots of adults even when initiated as late as 6 weeks of age.
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References
Knittle, J. L. & Hirsch, J. J. clin. Invest. 47, 2091–2098 (1968).
Hirsch, J. & Han, P. W. J. Lipid Res. 10, 77–82 (1969).
Hirsch, J. & Knittle, J. L. Fed Proc. 29, 1516–1521 (1970).
Oscai, L. B., Spirakis, C. N., Wolff, C. A. & Beck, R. J. J. Lipid Res. 13, 588–592 (1972).
Oscai, L. B., Babirak, S. P., Dubach, F. B., McGarr, J. A. & Spirakis, C. N. Am. J. Physiol. 227, 901–904 (1974).
Stiles, J. W., Francendese, A. A. & Masoro, E. J. Am. J. Phyisol. 229, 1561–1568 (1975)
Johnson, P. R., Zucker, L. M., Cruce, J. A. F. & Hirsch, J. J. Lipid Res. 12, 706–714 (1971).
Greenwood, M. C. R. & Hirsch, J. J. Lipid Res. 15, 484–493 (1974).
Schemmel, R., Mickelsen, O. & Mostosky, U. Anat. Rec. 166, 437–445 (1970).
Herberg, L., Doppen, W., Major, E. & Gries, F. A. J. Lipid Res. 15, 580–585 (1974).
DiGirolamo, M. & Mendlinger, S. Am. J. Physiol. 221, 859–864 (1971).
DiGirolamo, M., Mendlinger, S. & Fertig, J. W. Clin. Res. 17, 22 (1969).
Knittle, J. L. in Childhood Obesity (ed. Winick, M.) 135–140 (Wiley, New York, 1975).
Lemmonnier, D. J. clin. Invest. 51, 2907–2915 (1972).
Lemmonnier, D., Alexiu, A. & Lanteaume, M. T. J. Physiol. Paris 66 729–733 (1973).
Lemmonnier, D. Nutr. Metab. 16, 15–29 (1974).
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BERTRAND, H., MASORO, E. & Yu, B. Post-weaning food restriction reduces adipose cellularity. Nature 266, 62–63 (1977). https://doi.org/10.1038/266062a0
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DOI: https://doi.org/10.1038/266062a0
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