Cancer-induced cytolysis of normal bone marrow cells

Abstract

MOST investigations of the invasive process of cancer have involved microscopic studies of tumour spread after injection of cancer cells into experimental animals1–4. Attempts to investigate tumour invasiveness using organ or parabiotic cultures have met with limited success5–7. We have evaluated tumour-mediated cytolysis of normal rat marrow cells using suspension cultures containing Walker-256 carcinosarcoma cells and 59Fe-labelled rat bone marrow cells. This mixed cell culture system seems to provide a promising approach to the further understanding of cancer invasiveness.

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References

  1. 1

    Lockner, J., Goldblatt, P. J. & Leighton, J. Cancer 30, 1632–1644 (1970).

  2. 2

    Dingemans, K. P. J. natn. Cancer Inst. 53, 1813–1824 (1974).

  3. 3

    Woods, S. Jr, Baker, R. R. & Marzocchi, B. The Proliferation and Spread of Neoplastic Cells 495–506 (Williams and Wilkens, Baltimore).

  4. 4

    Babai, F. B. & Tremblay, G. Cancer Res. 32, 2765–2770 (1972).

  5. 5

    Easty, D. M. & Easty, G. C. Br. J. Cancer 29, 36–49 (1974).

  6. 6

    Yarnell, M. M. & Ambrose, E. J. Eur. J. Cancer 5, 265–269 (1969).

  7. 7

    Katsuta, H. and Takaoka, T. J. natn. Cancer Inst. 32, 963–980 (1964).

  8. 8

    Martz, E. Immunology 115, 261–267 (1975).

  9. 9

    Zucker, S. & Lysik, R. J. Lab. clin. Med. 84, 620–631 (1974).

  10. 10

    Storring, P. L. & Fatih, S. Biochim. biophys. Acta 392, 26–38 (1975).

  11. 11

    Lajtha, L. G. & Suit, H. D. Br. J. Haemat. 1, 55 (1955).

  12. 12

    Krantz, S. B., Moore, W. H. & Zaentz, S. D. J. clin. Invest. 52, 324–336 (1973).

  13. 13

    Stulting, R. D. & Berke, G. Cell. Immun. 9, 474–476 (1973).

  14. 14

    Campbell, R. C. Statistics for Biologist (Cambridge University Press, London, 1967).

  15. 15

    Walker, W. S. & Demus, A. J. Immun. 114, 765–769 (1975).

  16. 16

    Ralph, P. & Nakoinz, I. Nature 257, 393–394 (1975).

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ZUCKER, S., LYSIK, R. Cancer-induced cytolysis of normal bone marrow cells. Nature 265, 736–737 (1977). https://doi.org/10.1038/265736a0

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