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Novel N-terminal protein blocking group identified as dimethylproline

Nature volume 265, pages 661–662 (1977)Cite this article

Abstract

THE N-terminal region of Crithidia oncopelti cytochrome c557 could not be characterised by conventional methods because of an apparently blocked ammo function1. To study this feature the N-terminal tryptic peptide was isolated and 220 MHz proton magnetic resonance (PMR) spectroscopy was used to characterise this peptide and its hydrolysis products. We now report the identification of the novel blocking group as dimethylproline.

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Author notes

  1. GRAHAM W. PETTIGREW

    Present address: Department of Biochemistry, University of Sussex, Falmer Brighton, BN1 9QG, UK

Authors and Affiliations

  1. Department of Chemistry, University of California at San Diego, La Jolla, California, 92093

    GRAHAM W. PETTIGREW & GARY M. SMITH

Authors
  1. GRAHAM W. PETTIGREW
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  2. GARY M. SMITH
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PETTIGREW, G., SMITH, G. Novel N-terminal protein blocking group identified as dimethylproline. Nature 265, 661–662 (1977). https://doi.org/10.1038/265661a0

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  • DOI: https://doi.org/10.1038/265661a0

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