Insulin inhibition of antibody-dependent cytoxicity and insulin receptors in macrophages

Abstract

INSULIN receptors have been demonstrated on various human white blood cells including monocytes1,2 granulocytes3 and cultured lymphoblastoid cells4. Of these, the insulin receptor of the monocyte, a circulating macrophage, has been the most useful in the study of human disease5–9, although insulin has no known effect on macrophage function. We demonstrate here that cultured mouse macrophages10 and macrophage-containing cell populations from normal mouse spleens both possess specific receptors for insulin with properties indistinguishable from those of the human monocyte, and that insulin, at physiological concentrations, inhibits the ability of these cell populations to lyse antibody-coated red cells (antibody-dependent cell-mediated cytotoxicity or ADCC).

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BAR, R., KAHN, C. & KOREN, H. Insulin inhibition of antibody-dependent cytoxicity and insulin receptors in macrophages. Nature 265, 632–635 (1977). https://doi.org/10.1038/265632a0

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