Immunologic studies in contacts of osteosarcoma in humans and animals


AGENT(S) which could cause unrecognised or subclinical infections in otherwise healthy human household contacts of cancer patients may he detected by epidemiologic studies. Support for this hypothesis is provided by the reports of an increase in tumour specific humoral antibodies, as well as tumour specific cell mediated immunity1–4 in the household contacts of patients with osteosarcoma, adenocarcinoma of the breast and other malignancies. Clear evidence for the validity of this conclusion has not been obtained. To test this hypothesis, we studied antibodies (both humoral and cellular) in the household contacts of a patient with osteosarcoma. In addition, in an animal model for human osteosarcoma, we characterised the sera and lymphocytes of hamster mothers (in close contact with their offspring) before and after induction of the tumour in their immunosuppressed offspring.

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SINGH, I., TSANG, K. & BLAKEMORE, W. Immunologic studies in contacts of osteosarcoma in humans and animals. Nature 265, 541–542 (1977).

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