THE syndrome of senescence or aging is common to all living material. In many fungi the peripheral hyphae become senescent after prolonged vegetative growth, that is, their growth rate decreases and they eventually die. In some fungi, senescence is caused by transmissible elements, of temporarily if their metabolism is drastically reduced1,5, but anastomosis. The onset of senescence is influenced by environmental as well as genetical factors1–6. In Podospora anserina, where senescence has been very thoroughly analysed, it was shown that senescent mycelia may recover temporarily if their metabolism is drastically reduced1,5, the mycelia soon become senescent when grown in normal conditions. The nature of the senescent agent in Podospora is obscure. All efforts to demonstrate viruses or virus-like particles in aging hyphae of Podospora have failed (R. Bozarth, personal communication). Our endeavours to determine the nature and action of the senescent agent were encouraged by previous findings that the onset of senescence can be completely prevented by a synergistic action of specific genes6. In this paper we show that an antibiotic, tiamulin, can mimic the effect of these genes.
Subscribe to Journal
Get full journal access for 1 year
only $3.83 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Rent or Buy article
Get time limited or full article access on ReadCube.
All prices are NET prices.
Marcou, D., A. Sci. nat., 653–764 (1961).
Esser, K., and Kuenen, R., Genetics of Fungi (Springer-Verlag, Berlin, New York, 1967).
Bertrand, H., McDougall, K. J., and Pittenger, T. H., J. gen. Microbiol., 50, 337–350 (1968).
Holliday, R., Nature, 221, 1224–1228 (1969).
Smith, J. R., and Rubenstein, I., J. gen. Microbiol., 76, 283–296 (1973).
Esser, K., and Keller, W., Molec. gen. Genet., 144, 107–110 (1976).
Razin, S., Adv. Microbiol. Physiol., 10, 1–80 (1973).
Smith, P. F., The Biology of Mycoplasms (Academic, New York, 1972).
Ross, I. K., Pommerville, J. C., and Damm, D. L., J. Cell Sci., 21, 175–191 (1976).
About this article
Cite this article
ESSER, K., TUDZYNSKI, P. Prevention of senescence in the ascomycete Podospora anserina by the antibiotic tiamulin. Nature 265, 454–456 (1977). https://doi.org/10.1038/265454a0
From aging to virulence: forging connections through the study of copper homeostasis in eukaryotic microorganisms
Current Opinion in Microbiology (2004)
Ageing Research Reviews (2002)
Current Genetics (1983)
A model to explain senescence in the filamentous fungus Podospora anserina by the action of plasmid like DNA
Molecular and General Genetics MGG (1980)