Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Review Article
  • Published:

Homoeotic genes, compartments and cell determination in Drosophila

Nature volume 265, pages 211–216 (1977)Cite this article

Abstract

Normal development of Drosophila depends on the activity of certain ‘master’ genes. We review recent work which suggests that these genes control the developmental pathways taken by specific groups of cells as they divide and construct precisely defined parts of the adult fly.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Tazima, Y., The Genetics of the Silkworm (Academic, New York and London, 1964).

    Google Scholar 

  2. Sokoloff, A., The Genetics of Tribolium and Related Species (Academic, New York and London, 1966).

    Google Scholar 

  3. Lewis, E. B., Amer. Zool., 3, 33–56 (1963).

    Article  Google Scholar 

  4. Garcia-Bellido, A., Ripoll, P., and Morata, G., Nature new Biol., 245, 251–253 (1973).

    Article  CAS  PubMed  Google Scholar 

  5. Garcia-Bellido, A., Ripoll, P., and Morata, G., Devl Biol., 48, 132–147 (1976).

    Article  CAS  Google Scholar 

  6. Garcia-Bellido, A., and Santamaria, P., Genetics, 72, 87–107 (1972).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Sharma, R. P., and Chopra, V. L., Devl Biol., 48, 461–465 (1976).

    Article  CAS  Google Scholar 

  8. Morata, G., and Lawrence, P. A., Devl Biol. (in the press).

  9. Morata, G., J. Embryol. exp. Morph., 34, 19–31 (1975).

    CAS  PubMed  Google Scholar 

  10. Postlethwait, J. H., Schneiderman, H. A., Devl Biol., 25, 606–640 (1971).

    Article  CAS  Google Scholar 

  11. Gehring, W. J., and Schubiger, G., J. Embryol. exp. Morph., 33, 459–469 (1975).

    CAS  PubMed  Google Scholar 

  12. Ouweneel, W. J., Wilhelm Roux' Archiv., 167, 1–14 (1969).

    Article  Google Scholar 

  13. Denell, R. E., Genetics, 75, 279–297 (1973).

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Gehring, W., Arch. Julius Klaus-Stift, 41, 44–54 (1966).

    Google Scholar 

  15. Lindsley, D. L., and Grell, E. H., Genetic variations of Drosophila melanogaster (Carnegie Institute, Washington, 1968).

    Google Scholar 

  16. Lewis, E. B., in The Role of Chromosomes in Development, (edit, by Locke, M.), 231–252 (Academic, New York and London 1964).

    Book  Google Scholar 

  17. Lewis, E. B., in Heritage from Mendel (edit, by Brink, A.), 17–47 (University of Wisconsin Press, Madison 1967).

    Google Scholar 

  18. Hochman, B., Genetics, 67, 235–252 (1971).

    CAS  PubMed  PubMed Central  Google Scholar 

  19. Ripoll, P., and Garcia-Bellido, A., Nature new Biol., 241, 15–16 (1973).

    Article  CAS  PubMed  Google Scholar 

  20. Ferrus, A., and Garcia-Bellido, A., Nature, 260, 425–426 (1976).

    Article  ADS  CAS  PubMed  Google Scholar 

  21. Hadorn, E., Brookhaven Symp. Biol., 18, 148–161 (1965).

    Google Scholar 

  22. Gehring, W., and Nöthiger, R., in Developmental Systems: Insects (edit, by Counce, S., and Waddington, C. H.), 211–290 (Academic, New York and London, 1973).

    Google Scholar 

  23. Hadorn, E., and Buck, D., Rev. Suisse Zool., 69, 302–310 (1962).

    Google Scholar 

  24. Bryant, P. J., J. exp. Zool., 193, 49–78 (1975).

    Article  CAS  PubMed  Google Scholar 

  25. Schubiger, G., Wilhelm Roux' Archiv., 160, 9–40 (1968).

    Article  Google Scholar 

  26. Nöthiger, R., Wilhelm Roux' Archiv., 155, 269–301 (1964).

    Article  Google Scholar 

  27. Garcia-Bellido, A., Devl Biol., 14, 278–306 (1966).

    Article  CAS  Google Scholar 

  28. Gehring, W., Devl Biol., 16, 438–456 (1967).

    Article  CAS  Google Scholar 

  29. Hadorn, E., Devl Biol., 7, 617–629 (1963).

    Article  Google Scholar 

  30. Haynie, J., and Bryant, P. J., Nature, 259, 659–662 (1976).

    Article  ADS  CAS  PubMed  Google Scholar 

  31. Chan, L. N., and Gehring, W., Proc. natn. Acad. Sci. U.S.A., 68, 2217–2221 (1971).

    Article  ADS  CAS  Google Scholar 

  32. Illmensee, K., in Insect Development (edit, by Lawrence, P. A.), (Blackwells, Oxford, 1976).

    Google Scholar 

  33. Wieschaus, E., and Gehring, W., Devl Biol., 50, 249–263 (1976).

    Article  CAS  Google Scholar 

  34. Steiner, E., Wilhelm Roux' Archiv., 180, 9–30.

  35. Lawrence, P. A., and Morata, G., Devl Biol., (in the press).

  36. Anderson, D. T., J. Embryol. exp. Morph., 11, 339–351 (1963).

    Google Scholar 

  37. Gloor, H., Rev. Suisse Zool., 54, 637–712 (1947).

    Google Scholar 

  38. Capdevila, M. P., and Garcia-Bellido, A., Nature new Biol., 250, 500–502 (1974).

    Article  ADS  CAS  Google Scholar 

  39. Auerbach, C., Trans. R. Soc. Edinb., 58, 787–815 (1936).

    Google Scholar 

  40. Laugé, G., C. r. hebd. Séanc. Acad. Sci. Paris, 265, 814–817 (1967).

    Google Scholar 

  41. Garcia-Bellido, A., Genetics, 59, 487–499 (1968).

    CAS  PubMed  PubMed Central  Google Scholar 

  42. Garcia-Bellido, A., and Lewis, E. B., Devl Biol., 48, 400–410 (1976).

    Article  CAS  Google Scholar 

  43. Morata, G., and Garcia-Bellido, A., Wilhelm Roux' Archiv., 179, 125–143 (1976).

    Article  CAS  Google Scholar 

  44. Kaufman, T. C., Tasaka, S. E., and Suzuki, D. T., Genetics, 75, 299–321 (1973).

    CAS  PubMed  PubMed Central  Google Scholar 

  45. Garcia-Bellido, A., and Merriam, J. R., Proc. natn. Acad. Sci. U.S.A., 68, 2222–2226 (1971).

    Article  ADS  CAS  Google Scholar 

  46. Morata, G., and Lawrence, P. A., Nature, 225, 614–617 (1975).

    Article  ADS  Google Scholar 

  47. Lawrence, P. A., and Morata, G., Devl Biol., 50, 321–337 (1976).

    Article  CAS  Google Scholar 

  48. Garcia-Bellido, A., and Ferrus, A., Wilhelm Roux' Archiv., 178, 337–340 (1975).

    Article  CAS  Google Scholar 

  49. Postlethwait, J. H., and Girton, J. R., Genetics, 76, 767–774 (1974).

    CAS  PubMed  PubMed Central  Google Scholar 

  50. Grigliatti, T., and Suzuki, D. T., Proc. natn. Acad. Sci. U.S.A., 68, 1307–1311 (1971).

    Article  ADS  CAS  Google Scholar 

  51. Schubiger, G., and Alpert, G. D., Devl Biol., 42, 292–304 (1975).

    Article  CAS  Google Scholar 

  52. Garcia-Bellido, A., Genetics, 60, 181 (1968).

    Google Scholar 

  53. Bryant, P. J., Devl Biol., 22, 389–411 (1970).

    Article  CAS  Google Scholar 

  54. Garcia-Bellido, A., and Merriam, J. R., Devl Biol., 24, 61–87 (1971).

    Article  CAS  Google Scholar 

  55. Lawrence, P. A., J. Embryol. exp. Morph., 30, 681–699 (1973).

    CAS  PubMed  Google Scholar 

  56. Morata, G., and Ripoll, P., Devl Biol., 42, 211–221 (1975).

    Article  CAS  Google Scholar 

  57. Crick, F. H. C., and Lawrence, P. A., Science, 189, 340–347 (1975).

    Article  ADS  CAS  PubMed  Google Scholar 

  58. Stern, C., J. Morph., 67, 107–122 (1940).

    Article  Google Scholar 

  59. Garcia-Bellido, A., and Merriam, J. R., J. exp. Zool., 170, 61–75 (1969).

    Article  CAS  PubMed  Google Scholar 

  60. Bryant, P. J., and Schneiderman, H. A., Devl Biol., 20, 263–290 (1969).

    Article  CAS  Google Scholar 

  61. Ripoll, P., Wilhelm Roux' Archiv., 169, 200–215 (1972).

    Article  CAS  Google Scholar 

  62. Garcia-Bellido, A., in Cell Patterning, 161–182 (Ciba Foundation, North Holland, 1975).

    Google Scholar 

  63. Sander, K., in Cell Patterning, 241–263 (Ciba Foundation, North Holland, 1975).

    Google Scholar 

  64. Schubiger, G., Devl Biol., 50, 476–488 (1976).

    Article  CAS  Google Scholar 

  65. Mintz, B., Symp. Soc. exp. Biol., 25, 345–369 (1971).

    CAS  PubMed  Google Scholar 

  66. Gardner, R. L., and Rossant, J., in Embryogenesis in Mammals, 5–25 (Ciba Foundation, North Holland, 1976).

    Google Scholar 

  67. Lawrence, P. A., in Cell Patterning, 3–23 (Ciba Foundation, North Holland, 1975).

    Google Scholar 

  68. Diamond, J., Cooper, E., Turner, C., and Macintyre, L., Science, 193, 371–377 (1976).

    Article  ADS  CAS  PubMed  Google Scholar 

Download references

Author information

Author notes

  1. Gines Morata

    Present address: Centre de Biologia Molecular, CSIC, Facultad de Ciencias, C-X, Universidad Autonoma de Madrid, Madrid, 34, Spain

Authors and Affiliations

  1. MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK

    Gines Morata & Peter A. Lawrence

Authors
  1. Gines Morata
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Peter A. Lawrence
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Morata, G., Lawrence, P. Homoeotic genes, compartments and cell determination in Drosophila. Nature 265, 211–216 (1977). https://doi.org/10.1038/265211a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/265211a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing