Abstract
CELLULAR defects of chemotaxis are rare disorders1. Little is known about the cellular mechanisms of the chemotactic response, and in most cases the nature of the defect remains obscure. Singh et al. have reported defective chemotaxis in association with a chromosomal abnormality2. In their patient, bone marrow cells were tetraploid. In most cells a chromosome 16 was missing and there was an extra C-group chromosome. We investigated neutrophil granulocyte function in haematological disorders. Our results from a study of neutrophil function in five patients with monosomy-7 seem to suggest an association between this chromosome abnormality and defective chemotaxis.
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References
Ward, P. A., Am. J. Path., 77, 520–538 (1974).
Singh, H., et al., Lancet, i, 873–879 (1972).
Saarni, M. I., and Linman, J. W., Am. J. Med., 55, 38–48 (1973).
Baum, J., Mowat, A., and Kirk, J., Clin. Res., 18, 422 (1970).
Frei, P., Baisero, M., and Ochsner, M., in Antibiotics and Chemotherapy, Chemotaxis: Its Biology and Biochemistry (edit. by Sorkin, E.), 19, 350–361 (S. Karger, Basel, 1974).
Ruutu, T., Ruutu, P., Vuopio, P., Franssila, K., and Linder, E., Scand. J. Haemat., 15, 27–34 (1975).
Zigmond, S., and Hirsch, J., J. exp. Med., 137, 387–410 (1973).
De la Chapelle, A., Vuopio, P., and Icèn, A., Blood, 47, 815–826 (1976).
Rowley, J., and Potter, D., Blood, 47, 705–721 (1976).
Ruutu, T., Ruutu, T., Vuopio, P., Kounen, T.U., and de la Chapelle, A., Scand. J. Haemat. (in the press).
de la Chapelle, A., Vuopio, P., Sanger, R., and Teesdale, P., Lancet, ii, 817 (1975).
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RUUTU, P., RUUTU, T., VUOPIO, P. et al. Defective chemotaxis in monosomy-7. Nature 265, 146–147 (1977). https://doi.org/10.1038/265146a0
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DOI: https://doi.org/10.1038/265146a0
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