Abstract
DURING the course of our research in multiple sclerosis it was observed that apparently healthy laboratory personnel who had been artificially and accidentally exposed to brain tissue showed patterns of hypersensitivity inconsistent with our basic control group. We determined at that time to study them further as a separate group. Twelve people have been identified and studied. We subsequently categorised the types of exposure into three classes as shown in Table 1.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Eng, L. F., Vanderhaeghen, J. J., Bignami, A., and Gerstl, B., Brain Res., 28, 351–354 (1971).
Uyeda, C. T., Eng, L. F., and Bignami, A., Brain Res., 37, 81–89 (1972).
Kabat, E. A., Wolf, A., and Bezer, A. E., J. exp. Med., 85, 117–130 (1947).
Paterson, P. Y., in Textbook of Immunopathology, (edit. by Miescher, P. A., and Muller-Eberhard, H. J.), 132–149 (Grune and Stratton, New York, 1968).
Colby, S. P., Sheremata, W., Bain, B., and Eylar, E. H., Neurology (in the press).
Sheremata, W., Cosgrove, J. B. R., and Eylar, E. H., Trans. Am. Neur. Ass., 99, 77–182 (1974).
Van den Noort, S., and Stjernholm, R. L., Neurology (Minneap.), 21, 783–793 (1971).
Stjernholm, R. L., Wheelock, E. F., and Van den Noort, S., J. Reticuloendothel. Soc., 8, 334–341 (1970).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
UYEDA, C., MURPHY, P. Hypersensitivity to purified brain proteins in healthy individuals. Nature 264, 650–652 (1976). https://doi.org/10.1038/264650a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/264650a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.