Abstract
SINCE the first demonstration that silicone rubber1 could be used as an implantable carrier for sustained delivery of low molecular weight compounds in animal tissues, various drug delivery systems have been developed. But except for the reports of Davis2,3 and Girnbrone et al.4, there has been little success in the development of slow release agents for large molecular weight compounds. Furthermore, the polymers used in those studies, polyvinylpyrrolidone and polyacrylamide, are often inflammatory in animal tissues and usually permit only brief periods of sustained release. We now present a simple method for incorporating various proteins and other macromolecules into non-inflammatory polymers. Sustained release of biochemically active macromolecules has been demonstrated for periods exceeding 100 d.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Contribution of tetrodotoxin-resistant persistent Na+ currents to the excitability of C-type dural afferent neurons in rats
The Journal of Headache and Pain Open Access 28 June 2022
-
Shape-specific microfabricated particles for biomedical applications: a review
Drug Delivery and Translational Research Open Access 13 March 2022
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Get just this article for as long as you need it
$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Folkman, J., and Long, D. M., J. surg. Res., 4, 139–142 (1964).
Davis, B. K., Experientia, 28, 348 (1972).
Davis, B. K., Proc. natn. Acad. Sci. U.S.A., 71, 3120–3123 (1974).
Gimbrone, M. A., Jr, Cotran, R. S., Leapman, S. B., and Folkman, J., J. natn. Cancer Inst., 42, 314–427 (1974).
Fromer, C. H., and Klintworth, G. K., Am. J. Path., 79, 537–554 (1975).
Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. biol. Chem. 193, 265–275 (1951).
Bittner, T., and Muir, H., Analyt. Biochem., 4, 330–334 (1962).
Furano, A. V., Analyt. Biochem., 43, 639–640 (1972).
Soeldner, J. S., and Salone, D., Diabetes, 14, 771 (1965).
Carlsson, L., and Karlsson, B., Experientia, 28, 990–991 (1972).
Schill, W. R., and Schumacher, G. F. B., Analyt. Biochem., 46, 502–533 (1972).
Schumacher, G. F. B., and Schill, W. R., Analyt. Biochem., 48, 9–26 (1972).
Folkman, J., Cancer Res., 34, 2109–2113 (1974).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
LANGER, R., FOLKMAN, J. Polymers for the sustained release of proteins and other macromolecules. Nature 263, 797–800 (1976). https://doi.org/10.1038/263797a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/263797a0
This article is cited by
-
mRNA therapy at the convergence of genetics and nanomedicine
Nature Nanotechnology (2023)
-
Contribution of tetrodotoxin-resistant persistent Na+ currents to the excitability of C-type dural afferent neurons in rats
The Journal of Headache and Pain (2022)
-
The landscape of mRNA nanomedicine
Nature Medicine (2022)
-
Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity
Nature Biomedical Engineering (2022)
-
Shape-specific microfabricated particles for biomedical applications: a review
Drug Delivery and Translational Research (2022)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
