Abstract
CYTOTOXIC T lymphocytes generated during a unidirectional mixed lymphocyte culture (MLC) lyse target cells which have the antigenic phenotype of the allogeneic stimulating cells. The cytotoxic effect is restricted to cells that bear the same major histocompatibility antigens (H–2 antigens in mice) as the stimulating cells1. H–2 restriction of cytotoxicity is also seen when immune T lymphocytes react in vitro to cells bearing viral2, chemical3, or minor histocompatibility antigens4 or following autosensitisation against unmodified fibroblasts5. Thus, H–2 restriction of cytotoxic lymphocytes has been observed in many circumstances. We now report that cultures of normal spleen cells generate T lymphocytes that damage target cells regardless of their H–2 phenotype.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Hayry, P., and Defendi, V., Science, 168, 133–135 (1970).
Zinkernagel, R. M., and Doherty, P. C., J. exp. Med., 141, 1427–1436 (1975).
Shearer, G. M., Rehn, T. G., and Garvarino, C. A., J. exp. Med., 141, 1348–1364 (1975).
Gordon, R. D., Simpson, E., and Samelson, L. E., J. exp. Med., 142, 1108–1120 (1975).
Ilfeld, D., Carnaud, C., and Klein, E., Immunogenetics, 2, 231–240 (1975).
Raff, M. C., Immunology, 19, 637–650 (1970).
Wagner, H., Harris, A. W., and Feldmann, M., Cell. Immun., 4, 39–50 (1972).
Wagner, H., Feldmann, M., Boyle, W., and Schrader, J. W., J. exp. Med., 136, 331–343 (1972).
Anderson, J., Sjoberg, O., and Moller, G., Transplant. Rev., 11, 131–177 (1972).
Forni, G., and Green, T., J. Immun., 166, 1561–1565 (1976).
Hodes, R. J., and Hathcock, R. S., J. Immun., 116, 167–177 (1976).
Burns, F. D., Marrack, P. C., Kappler, J. W., and Janeway, C. A., J. Immun., 114, 1345–1347 (1975).
Jandinski, J., Cantor, H., Tadakuma, T., Peavy, D. L., and Pierce, C. W., J. exp. Med., 143, 1382–1390 (1976).
Cantor, H., and Boyse, E. A., J. exp. Med., 141, 1376–1389 (1975).
Wekerle, H., Lonai, P., and Feldmann, M., Proc. natn. Acad. Sci. U.S.A., 69 1620–1624 (1972).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SHUSTIK, C., COHEN, I., SCHWARTZ, R. et al. T lymphocytes with promiscuous cytotoxicity. Nature 263, 699–701 (1976). https://doi.org/10.1038/263699a0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/263699a0
This article is cited by
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.