Abstract
POLYCHLORINATED biphenyls (PCBs) are widely used industrial chemicals which have found their way into the environment, where they have been detected in rainwater, in many species of birds and fish and in human tissues. PCBs accumulate in the body's fat tissues, where they apparently degrade very slowly under natural conditions1, but recently it has been found2 that PCBs may act as carcinogens. The detailed actions of PCBs inside the body, such as their effects on carbohydrate, lipid or protein metabolism, are relatively unknown although they have been shown to alter the liver cell in mouse and monkey3, to affect the immune system4 and to alter the activity of microsomal and other enzyme systems5–8. We have studied the in vivo effect of PCBs on the activity of two regulatory enzymes of gluconeogenesis, phosphopenol-pyruvate carboxykinase (PEPCK) and fructose-1, 6-diphosphatase (FDPase), respectively, in rat liver.
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MESSNER, B., BERNDT, J. & STILL, J. Inhibition of PEP-carboxykinase in rat liver by polychlorinated biphenyl. Nature 263, 599–600 (1976). https://doi.org/10.1038/263599a0
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DOI: https://doi.org/10.1038/263599a0
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