Abstract
PROTECTIVE antibodies are involved in acquired immunity to malaria parasites1. Sera from monkeys immune to Plasmodium knowlesi contain antibodies which depress multiplication of the parasite in vitro2 by, it is believed, inhibiting the invasion of red cells by merozoites3,4. Antibodies inhibitory to parasites of a specific antigenic variant are of a higher titre than inhibitory antibodies which cross-react with different antigenic variants5. We have attempted to extend these findings to natural human infections with P. falciparum in The Gambia, West Africa, where P. falciparum malaria is hyperendemic. The entire population is exposed to infection and an effective immunity is only acquired over 4–5 yr (ref. 6). Immunity to P. falciparum can be passively transferred with IgG from immune Gambian adults7.
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WILSON, R., PHILLIPS, R. Method to test inhibitory antibodies in human sera to wild populations of Plasmodium falciparum. Nature 263, 132–134 (1976). https://doi.org/10.1038/263132a0
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DOI: https://doi.org/10.1038/263132a0
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