PROGESTERONE injection given 24 h or more before ovulation inhibits the ovulatory cycle1–5. There is evidence that progesterone can act directly on the hypothalamus6–9 to block ovulation and on the pituitary to reduce pituitary sensitivity to luteinising releasing hormone10,11. Steroid-sensitive target tissues including hypothalamus12,13 and pituitary14–16 contain a specific oestrogen retention mechanism of limited capacity. Oestrogen-regulated events can be demonstrated only in the presence of a functional retention (receptor) system for oestrogen. In contrast, no specific progesterone retention system has yet been demonstrated for hypothalamus or pituitary. Does progesterone interact with these target tissues in a novel manner? This seems unlikely since other steroids which have been studied—for example, adrenal corticoids17 and androgens18—have been found to bind to specific receptors in their target tissues. We therefore tested an alternate possibility that progesterone action on hypothalamus and pituitary might result in modification of the oestrogen receptor system. We tested 3H-oestradiol retention by hypothalamus and pituitary after in vivo treatment with progesterone (subcutaneous pellet; release rate=1.5–3 mg d−1) of various durations from hours to days. In vitro 3H-oestradiol-specific retention by oestradiol–receptor complexes transferred to the nuclear fraction of these tissues was also compared for animals receiving previous in vivo progesterone treatment compared with ovariectomised animals not receiving progesterone treatment.
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About this article
Ultrasound-induced Parental Behaviour in House Mice is Controlled by Female Sex Hormones and Parental Experience
Cytosol and nuclear estrogen receptor binding in the preoptic area and hypothalamus of female rats during pregnancy and ovariectomized, nulliparous rats after steroid priming: Correlation with maternal behavior
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