TARGET cells acutely infected with herpes simplex virus (HSV) can be destroyed by human blood mononuclear cells (MC) in the presence of IgG antibody to HSV1–3, a process termed antibody-dependent cellular cytotoxicity (ADCC). The major effector cell which mediates this reaction is a K cell; it possesses surface Fc receptors which permit attachment to IgG antibody-sensitised target cells4–6, although the way in which the lethal hit is delivered is poorly understood. For an immune cytolytic mechanism to be maximally effective in limiting the spread of virus in a host, it should be able to destroy the infected cell at an early stage in the viral maturation cycle, before infectious viral progeny can be produced. This requirement seems to be of particular importance for viruses such as HSV, which can avoid exposure to the neutralising antibody in extracellular fluid by spreading from cell to cell across intercellular bridges7,8. In this report, we demonstrate that the ADCC mechanism can recognise viral surface antigens as early as 2 h after cells are infected with HSV and can produce target cell death by 3 h after infection (PI), well in advance of the first appearance of both viral progeny and the susceptibility of infected cells to lysis by antibody and complement (AbC).
Access optionsAccess options
Subscribe to Journal
Get full journal access for 1 year
only $3.90 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Rent or Buy article
Get time limited or full article access on ReadCube.
All prices are NET prices.
Shore, S. L., Nahmias, A. J., Starr, S. E., Wood, P. A., and McFarlin, D. E., Nature, 251, 350–352 (1974).
Rager-Zisman, B., and Bloom, B., Nature, 251, 542–543 (1974).
Shore, S. L., Black, C. M., Melewicz, F. M., Wood, P. A., and Nahmias, A. J., J. Immun., 116, 194–201 (1976).
Larsson, A., and Perlmann, P., Int. Archs. Allergy, 43, 80–88 (1972).
Shore, S. L., Melewicz, F. M., Milgrom, H., and Nahmias, A. J., in The Reticulo-endothelial System in Health and Disease (edit. by Reichard, S. M., Escobar, M. R., and Friedman, H.), (Plenum, New York, in the press).
Romano, T. J., and Shore, S. L., Fedn Proc., 35, 474 (1976).
Hoggan, D. B., Roizman, B., and Roane, P. R., Am. J. Hyg., 73, 114–122 (1961).
Christian, R. T., and Ludovici, P. P., Proc. Soc. exp. Biol. Med., 138, 1109–1115 (1971).
Rosenthal, J., Hayashi, K., and Notkins, A. L., J. gen. Virol, 18, 195–199 (1973).
Lodmell, D. L., Niwa, A., Hayashi, K., and Notkins, A. L., J. exp. Med., 137, 706–720 (1973).
Perlmann, P., Perlmann, H., and Wigzell, H., Transplant. Rev., 13, 91–114 (1972).
About this article
Monoclonal Antibodies, Derived from Humans Vaccinated with the RV144 HIV Vaccine Containing the HVEM Binding Domain of Herpes Simplex Virus (HSV) Glycoprotein D, Neutralize HSV Infection, Mediate Antibody-Dependent Cellular Cytotoxicity, and Protect Mice from Ocular Challenge with HSV-1
Journal of Virology (2017)
Journal of Immunological Methods (2013)
Antibody-Dependent Cellular Cytotoxicity via Humoral Immune Epitope of Nef Protein Expressed on Cell Surface
The Journal of Immunology (2004)
Serum and effector-cell antibody-dependent cellular cytotoxicity (ADCC) activity remains high during human immunodeficiency virus (HIV) disease progression
Journal of Clinical Immunology (1989)