Inhibition of Leishmania donovani transformation by hamster spleen homogenates and active human lymphocytes

Abstract

HAEMOFLAGELLATES are protozoan parasites responsible for many important diseases of man and domestic animals1. Leishmania donovani, the cause of visceral leishmaniasis or kala azar, is a widespread human parasitic haemoflagellate. Its life cycle involves man (and other mammals) and an insect vector (sandflies) with a different stage in each of the two host types. Transformation from one stage to the next includes morphological antigenic, physiological, and infectivity changes2–5.

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References

  1. 1

    Hoare, C. A., Trypanosomes of Mammals, 60–80 (Blackwell Scientific, Oxford, 1972).

  2. 2

    Simpson, L., J. Protozool., 15, 210–207 (1968).

  3. 3

    Honiberg, B. M., in Chemical Zoology, 1 (edit. by Florkin. M. and Scheen B. T.) 711–759 (Academic, New York and London, 1967).

  4. 4

    Bowman, I. B. R., Srivistava, H. K., and Flynn, I. W., in Comparative Biochemistry of Parasites (edit by Van Den Bossche, H.), 329–342 (Academic New York and London, 1972).

  5. 5

    von Brand, T., Biochemistry of Parasites, 368–425 (Academic, New York and London, 1973).

  6. 6

    Stevens, L. A., J. Parasitol., 56 (II), 330 (1970).

  7. 7

    Berens, R., Brun, R., and Krassner, S. M., J. Parasitol. (in the press).

  8. 8

    Rutter, W. M., Pictet, R. L., and Morris, P. W., A. Rev. Biochem., 42, 601–646 (1973).

  9. 9

    Pastan, I. H., Johnson, G. S., and Anderson, W. B., A. Rev. Biochem., 44, 491–522 (1975).

  10. 10

    Kolb, W. P., Williams, T. W., and Granger, G. A., in In Vitro Methods in Cell-Mediated Immunity (edit. by Bloom, B. and Glade, P.), 333–342 (Academic, New York and London, 1971).

  11. 11

    Lamy, L. H., Protistologica, 6, 457–466 (1970).

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