Inhibition of Leishmania donovani transformation by hamster spleen homogenates and active human lymphocytes


HAEMOFLAGELLATES are protozoan parasites responsible for many important diseases of man and domestic animals1. Leishmania donovani, the cause of visceral leishmaniasis or kala azar, is a widespread human parasitic haemoflagellate. Its life cycle involves man (and other mammals) and an insect vector (sandflies) with a different stage in each of the two host types. Transformation from one stage to the next includes morphological antigenic, physiological, and infectivity changes2–5.

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