Changes in amino acid sensitivity during polypeptide ‘desensitisation’

Abstract

CURRENT interest in polypeptides as neurotransmitter substances in the central nervous system (CNS) has been focused on their ability to depolarise motoneurones1 and to excite single cells in various parts of the brain2–6. An additional feature of their actions on nervous tissue, however, is the development of ‘tachyphylaxis’ or ‘desensitisation’ to their effects during repeated administration. This phenomenon has been reported with two structurally related undecapeptides in particular, substance P and eledoisin, both in spinal cord7 and in brain3–5. We report here that in the substantia nigra additional changes in amino acid sensitivity occur during such a period of desensitisation to eledoisin.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Otsuka, M., Konishi, S., and Takahashi, T., Fedn Proc., 34, 1922–1928 (1975).

  2. 2

    Krnjevic, K., and Morris, M. E., Can. J. Physiol. Pharmac., 52, 736–744 (1974).

  3. 3

    Phillis, J. W., and Limacher, J. J., Brain Res., 69, 158–163 (1974).

  4. 4

    Henry, J. L., Krnjevic, K., and Morris, M. E., Can. J. Physiol. Pharmac., 53, 423–432 (1975).

  5. 5

    Davies, J., and Dray, A., Brain Res., 107, 623–627 (1976).

  6. 6

    Walker, R. J., Kemp, J. A., Yajima, H., Kitagawa, K., and Woodruff, G. N., Experientia, 32, 214–215 (1976).

  7. 7

    Evans, R. H., Francis, A. A., and Watkins, J. C., Br. J. Pharmac. (in the press).

  8. 8

    Dray, A., Gonye, T. J., and Oakley, N. R., J. Physiol., Lond. (in the press).

  9. 9

    Dray, A., and Straughan, D. W., J. Pharm. Pharmac., Suppl., 28, 400–405 (1976).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.