In vitro inhibition of cyclic AMP phosphodiesterase by cortisol

Abstract

HORMONAL effects on cyclic nucleotide phosphodiesterase activity are assumed to play an important role in the regulation of intracellular cyclic nucleotide concentrations1. The respective hormones vary widely with respect to function and structure, and comprise polypeptides, biogenic amines, and steroids including the glucocorticoids2–4. In no case, however, has the mechanism of hormonal action on cyclic AMP phosphodiesterase clearly been established. It is not known whether the enzyme itself is the primary point of attack by the hormone or whether the observed changes in enzyme activity (for review, see ref. 1) are side-effects of hormonal action, since no conclusive in vitro studies have been undertaken so far.

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