Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Membrane action of DMSO and other chemical inducers of Friend leukaemic cell differentiation

Nature volume 262, pages 360–363 (1976)Cite this article

Abstract

DMSO and other cryoprotective agents produce a pronounced increase on the phase transition temperature of phospholipid membranes, indicating an increased stability. The effects of DMSO and the other cryoprotective agents, divalent cations, and local anaesthetics on the transition temperature of phospholipid membranes seem to correlate with their effects on the differentiation of Friend leukaemic cells in vitro. These studies suggest that the induction of differentiation by cryoprotective agents may be the result of the interaction of these agents with cell membranes.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Preisler, H. D., and Lyman, G. H., Cell Differentiation, 4, 179–815 (1975).

    Article  CAS  Google Scholar 

  2. Preisler, H. D., Christoff, G., and Taylor, E., Blood, 47, 363–368 (1976).

    Article  CAS  Google Scholar 

  3. Preisler, H. D., Houseman, D., Scher, W., and Friend, C., Proc. natn. Acad. Sci. U.S.A., 70, 2956–2959 (1973).

    Article  ADS  CAS  Google Scholar 

  4. Pollack, R. E., and Hough, P. V. C., A. Rev. Med., 25, 431–446 (1974).

    Article  CAS  Google Scholar 

  5. Ladbrooke, B. D., and Chapman, D., Chem. phys. Lipids, 3, 304–356 (1969).

    Article  CAS  Google Scholar 

  6. Hinz, H. J., and Sturtevant, J. M., J. biol. Chem., 247, 6071–6075 (1972).

    PubMed  CAS  Google Scholar 

  7. Linden, C. D., Wright, K. L., McConnell, H. M., and Fox, C. F., Proc. natn. Acad. Sci. U.S.A., 70, 2271–2275 (1973).

    Article  ADS  CAS  Google Scholar 

  8. Overath, P., and Trauble, H., Biochemistry, 12, 2625–2634 (1973).

    Article  CAS  Google Scholar 

  9. Raison, J. K., J. Bioenerg., 4, 285–309 (1973).

    Article  CAS  Google Scholar 

  10. Hubbell, W. L., Metcalfe, J. C., Metcalfe, S. M., and McConnell, H. M., Biochim. biophys. Acta, 219, 415–427 (1970).

    Article  CAS  Google Scholar 

  11. Papahadjopoulos, D. Jacobson, K., Poste, G., and Shepard, G., Biochim. biophys. Acta, 394, 504–519 (1975).

    Article  CAS  Google Scholar 

  12. Papahadjopoulos, D., Jacobson, K., Nir, S., and Isac, T., Biochim. biophys. Acta, 311, 330–348 (1973).

    Article  CAS  Google Scholar 

  13. Bangham, A. D., Standish, M. M., and Watkins, J. C., J. molec. Biol., 13, 238–252 (1965).

    Article  CAS  Google Scholar 

  14. Leder, A., and Leder, P., Cell, 5, 319–322 (1975).

    Article  CAS  Google Scholar 

  15. Rammler, D. H., and Zafferoni, A., Ann. N. Y. Acad. Sci., 141, 13–23 (1967).

    Article  ADS  CAS  Google Scholar 

  16. Colley, C. M., and Metcalfe, J. C., FEBS Lett., 24, 241–246 (1972).

    Article  CAS  Google Scholar 

  17. Jacobson, K., and Papahadjopoulos, D., Biochemistry, 14, 152–161 (1975).

    Article  CAS  Google Scholar 

  18. Trauble, H., and Eibl, H., Proc. natn. Acad. Sci. U.S.A., 71, 214–219 (1974).

    Article  ADS  CAS  Google Scholar 

  19. Bernstein, A., Boyd, A. S., Brichley, V., and Lamb, V., in Biogenisis and Turnover of Membrane Macromolecules (edit. by Cook, J. S.), 145–159 (Raven, New York, 1976).

    Google Scholar 

  20. Henderson, T. R., Henderson, R. F., and Johnson, G. E., Arch. Biochem. Biophys., 132, 242–248 (1969).

    Article  CAS  Google Scholar 

  21. Herskovits, T. T., Archs Biochem. Biophys., 97, 474–484 (1962).

    Article  CAS  Google Scholar 

  22. Lyman, G. H., Papahadjopoulos, D., and Preisler, H. D., Biochim. biophys. Acta (in the press).

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, Roswell Park Memorial Institute, 666 Elm Street, Buffalo, New York, 14263

    Gary H. Lyman & Harvey D. Preisler

  2. Department of Experimental Pathology, Roswell Park Memorial Institute, 666 Elm Street, Buffalo, New York, 14263

    Demetrios Papahadjopoulos

Authors
  1. Gary H. Lyman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Harvey D. Preisler
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Demetrios Papahadjopoulos
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lyman, G., Preisler, H. & Papahadjopoulos, D. Membrane action of DMSO and other chemical inducers of Friend leukaemic cell differentiation. Nature 262, 360–363 (1976). https://doi.org/10.1038/262360a0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/262360a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing