Abstract
IN normal supporting tissue and repair tissue of animals collagen is usually considered to be produced by cells of mesenchymal origin. Little is known, however, about the type of cell which synthesises collagen in organs which undergo diffuse fibrosis without known physical trauma, such as in cirrhosis of the liver. Tissue culture has shown, however, that epithelial cells1, including cancer cells2 and smooth muscle cells3, can synthesise collagen. We report here that an epithelial clone, originating from the liver cell line of rat forms a considerable amount of native collagen in culture.
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SAKAKIBARA, K., SAITO, M., UMEDA, M. et al. Native collagen formation by liver parenchymal cells in culture. Nature 262, 316–318 (1976). https://doi.org/10.1038/262316a0
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DOI: https://doi.org/10.1038/262316a0
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