Abstract
THE Mason–Pfizer monkey virus (MPMV) was originally isolated from a spontaneous mammary carcinoma of a rhesus monkey1,2. Further isolates have been described from normal and malignant rhesus monkey tissues3. There have also been reports of viruses4–7, nucleic acids8 and antigens9 related to MPMV in human tissues. Viruses of the MPMV group have a density in sucrose of 1.16 g cm−3 (refs 10 and 11) and possess a segmented 60–70S RNA viral genome10–12 which contains polyadenylate sequences of about 200 nucleotides13. In addition, MPMV contains a reverse transcriptase 14,15 and structural polypeptides whose number and molecular weights resemble those of known type C RNA viruses16,17. In spite of these similarities with type C viruses, available evidence indicates that MPMV falls into a distinct group. This conclusion is based on morphological features that distinguish MPMV from type C viruses18, as well as differences in the biochemical properties of their reverse transcriptases15. Further, MPMV lacks detectable immunological cross reactivity with the 30,000 molecular weight (p30) major structural polypeptides of mammalian type C viruses5,16. The antigenic determinants shared by p30s of known mammalian type C viruses have been used extensively in the identification of new virus isolates and in the analysis of immunological relationships between type C viruses19,20. Other type C virus structural components such as gp70 also have been shown to possess broadly reactive antigenic determinants21,22. We have now purified and characterised the gp70s of an endogenous virus of the baboon, an old world primate and of MPMV. Our results provide evidence that MPMV is immunologically related to endogenous type C viruses of primates.
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STEPHENSON, J., HINO, S., GARRETT, E. et al. Immunological cross reactivity of Mason–Pfizer monkey virus with type C RNA viruses endogenous to primates. Nature 261, 609–611 (1976). https://doi.org/10.1038/261609a0
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DOI: https://doi.org/10.1038/261609a0
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